P8511
trans-2-Phenylcyclopropylamine hydrochloride
동의어(들):
Tranylcypromine
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
C6H5C3H4NH2·HCl
CAS 번호:
Molecular Weight:
169.65
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
MDL number:
InChI
1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7;/h1-5,8-9H,6,10H2;1H/t8-,9+;/m0./s1
SMILES string
Cl.N[C@@H]1C[C@H]1c2ccccc2
InChI key
ZPEFMSTTZXJOTM-OULXEKPRSA-N
biological source
synthetic (organic)
assay
≥97% (TLC)
form
powder
mp
162-169 °C (lit.)
solubility
ethanol: 50 mg/mL, clear to slightly hazy
storage temp.
2-8°C
Quality Level
Gene Information
human ... MAOA(4128), MAOB(4129)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
Biochem/physiol Actions
Non-selective MAO-A/B inhibitor.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
Navneet Goyal et al.
Journal of cancer metastasis and treatment, 7 (2021-11-02)
In this study, our goal was to study the inhibition of nicotine metabolism by P450 2A6, as a means for reduction in tobacco use and consequently the prevention of smoking-related cancers. Nicotine, a phytochemical, is an addictive stimulant, responsible for
Erin A Clark et al.
Cell reports, 27(12), 3522-3532 (2019-06-20)
KDM1A-mediated H3K4 demethylation is a well-established mechanism underlying transcriptional gene repression, but its role in gene activation is less clear. Here, we report a critical function and mechanism of action of KDM1A in glucocorticoid receptor (GR)-mediated gene transcription. Biochemical purification of
Navneet Goyal et al.
Chemical research in toxicology, 36(12), 1973-1979 (2023-11-14)
As a potential means for smoking cessation and consequently prevention of smoking-related diseases and mortality, in this study, our goal was to investigate the inhibition of nicotine metabolism by P450 2A6. Smoking is the main cause of many diseases and
Mingxi Weng et al.
Science advances, 9(34), eadh2501-eadh2501 (2023-08-23)
Advanced strategies to interconvert cell types provide promising avenues to model cellular pathologies and to develop therapies for neurological disorders. Yet, methods to directly transdifferentiate somatic cells into multipotent induced neural stem cells (iNSCs) are slow and inefficient, and it
Kaisa A Salminen et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(12), 1891-1904 (2015-09-25)
The cytochrome P450 2C19 (CYP2C19) enzyme plays an important role in the metabolism of many commonly used drugs. Relatively little is known about CYP2C19 inhibitors, including compounds of natural origin, which could inhibit CYP2C19, potentially causing clinically relevant metabolism-based drug
문서
Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.
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