P8765
Ammonium pyrrolidinedithiocarbamate
~99%
동의어(들):
1-Pyrrolidinecarbodithioic acid ammonium salt, APDC, Ammonium pyrrolidinecarbodithioate, PDC, PDTC
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
C5H9NS2 · NH3
CAS 번호:
Molecular Weight:
164.29
UNSPSC Code:
12352107
NACRES:
NA.77
PubChem Substance ID:
EC Number:
225-834-4
Beilstein/REAXYS Number:
3730472
MDL number:
제품 이름
Ammonium pyrrolidinedithiocarbamate, ~99%
InChI
1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
InChI key
MDDIUTVUBYEEEM-UHFFFAOYSA-N
SMILES string
N.SC(=S)N1CCCC1
biological source
microbial
assay
~99%
form
(powderor powder with lumps)
mp
153-155 °C (lit.)
solubility
water: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
storage temp.
2-8°C
Quality Level
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846), RELA(5970)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
관련 카테고리
Application
Ammonium pyrrolidinedithiocarbamate has been used:
to abrogate the microRNA-146a promoter luciferase reporter activity in human brain cells
- to inhibit nuclear factor κB (NF-κB) mobilization and TNF (tumor necrosis factor) production in human monocytes
- to reduce neutrophil activity in rats
- to prevent Ca2+ influx in adriamycin (ADR)-treated podocytes
to abrogate the microRNA-146a promoter luciferase reporter activity in human brain cells
Biochem/physiol Actions
Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.
General description
Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor. It functions as a chelating agent, which allows the preconcentration of trace metals from solution. Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells
Lukiw WJ, et al.
The Journal of Biological Chemistry, 283(46), 31315-31322 (2008)
Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells
Tsai JC, et al.
The Journal of Biological Chemistry, 271(7), 3667-3670 (1996)
Quan Zhou et al.
Oncogene, 39(7), 1414-1428 (2019-10-30)
Gastric cancer (GC) is characterized by extensive local invasion, distant metastasis and poor prognosis. In most cases, GC progression is associated with aberrant expression of cytokines or activation of signaling cascades mediated by tumor-stroma interactions. However, the mechanisms by which
Electron transport chain inhibitors induce microglia activation through enhancing mitochondrial reactive oxygen species production
Ye J, et al.
Experimental Cell Research, 340(2), 315-326 (2016)
Multi-element preconcentration of heavy metal ions from aqueous solution by APDC impregnated activated carbon
Daorattanachai P, et al.
Talanta, 67(1), 59-64 (2005)
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.