P9797
Pyridostigmine bromide
≥98% (HPLC), Acetylcholinesterase inhibitor, solid
동의어(들):
3-(Dimethylaminocarbonyloxy)-1-methylpyridinium bromide
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C9H13BrN2O2
CAS 번호:
Molecular Weight:
261.12
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
202-929-9
MDL number:
제품 이름
Pyridostigmine bromide,
InChI key
VNYBTNPBYXSMOO-UHFFFAOYSA-M
InChI
1S/C9H13N2O2.BrH/c1-10(2)9(12)13-8-5-4-6-11(3)7-8;/h4-7H,1-3H3;1H/q+1;/p-1
SMILES string
[Br-].CN(C)C(=O)Oc1ccc[n+](C)c1
assay
≥98% (HPLC)
form
solid
solubility
water: 100 mg/mL, clear to very slightly hazy, colorless
originator
Valeant
Quality Level
Gene Information
human ... ACHE(43)
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Application
Pyridostigmine bromide has been used as a cholinesterase inhibitor in mice, in florimetric assay for acetylcholine secretion and for measuring acetylcholine release from mice atrial tissue.
Biochem/physiol Actions
Acetylcholinesterase inhibitor.
Pyridostigmine bromide inhibits acetylcholine esterase and is membrane impermeable. It is used as a preventive medicine in chemical warfare. Pyridostigmine bromide is a carbamate compound comprising quaternary amine structure. It displays low absorption at the gastrointestinal tract. Sustained release of pyridostigmine is recommended for improving its bioavailability in treating myasthenia gravis.
Features and Benefits
This compound was developed by Valeant. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Skin Sens. 1
저장 등급
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
flash_point_f
No data available
flash_point_c
No data available
Preparation and in vitro evaluation of pyridostigmine bromide microparticles
Hegazy N, et al.
International Journal of Pharmaceutics, 242(1-2), 171-174 (2002)
Protein binding of isofluorophate in vivo after coexposure to multiple chemicals.
Vogel JS, et al.
Environmental Health Perspectives, 110(suppl 6), 1031-1036 (2002)
Benefits from sustained-release pyridostigmine bromide in myasthenia gravis: results of a prospective multicenter open-label trial
Sieb JP and Kohler W
Clinical Neurology and Neurosurgery, 112(9), 781-784 (2010)
Cardiomyocyte-secreted acetylcholine is required for maintenance of homeostasis in the heart
Roy A, et al.
Faseb Journal, 27(12), 5072-5082 (2013)
Gulf War and health Depleted uranium, pyridostigmine bromide, sarin, and vaccines (2000)
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