PZ0117

PF-573228

Name: PF-573228
Brand: SIGMA

≥95% (HPLC), FAK inhibitor, powder

동의어(들):

6-[4-(3-Methanesulfonyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one, PF-228

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₂H₂₀F₃N₅O₃S

CAS 번호:

869288-64-2

Molecular Weight:

491.49

UNSPSC Code:

12352200

PubChem Substance ID:

329823709

NACRES:

NA.77

MDL number:

MFCD11519967

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

100

주요 문서

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제품 이름

PF-573228, ≥95% (HPLC)

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)c1

InChI

1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30)

InChI key

HESLKTSGTIBHJU-UHFFFAOYSA-N

Biochem/physiol Actions

PF-573228 is a focal adhesion kinase (FAK) inhibitor; Non-receptor tyrosine kinase inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Fak page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

저장 등급

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

0000385750

0000187302

0000135660

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

KLF8 promotes invasive outgrowth of breast cancer by inducing filopodium-like protrusions via CXCR4.

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Merging of ventral fibers at adhesions drives the remodeling of cellular contractile systems in fibroblasts.

Shwetha Narasimhan et al.

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Ventral stress fibers (VSFs) are contractile actin fibers dynamically attached to cell-matrix focal adhesions. VSFs are critical in cellular traction force production and migration. VSFs vary from randomly oriented short, thinner fibers to long, thick fibers that span along the

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Patricia Costa et al.

PloS one, 8(9), e74659-e74659 (2013-09-17)

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Homeobox B7 accelerates the cancer progression of gastric carcinoma cells by promoting epithelial-mesenchymal transition (EMT) and activating Src-FAK pathway.

Jianghong Wu et al.

OncoTargets and therapy, 12, 3743-3751 (2019-06-14)

Aim: To study the carcinogenetic mechanism of HOXB7 in gastric cancer (GC) remains. Methods: Two human GC cell lines - SGC7901 and SNU1 - were used for this study. SGC7901 cells were transfected with siRNA-HOXB7 (siHOXB7) to knock down HOXB7

Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth.

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The Journal of biological chemistry, 292(6), 2065-2079 (2016-12-21)

Autophagy is an evolutionarily conserved intracellular degradation/recycling system that is essential for cellular homeostasis but is dysregulated in a number of diseases, including myocardial hypertrophy. Although it is clear that limiting or accelerating autophagic flux can result in pathological cardiac

모든 관련된 서류 보기

문서

Focal Adhesion Kinase (FAK) Overview

The focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase. FAK has been implicated as a downstream signaling molecule that functions in the control of several integrin-regulated biological processes.

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

초점 접착 키나아제(FAK) 개요

초점 접착 키나아제(FAK)는 세포질 단백질 티로신 키나아제이다. FAK는 여러 인테그린 조절 생물학적 과정의 제어에 기능하는 하류 신호 전달 분자로 관여하는 것으로 알려져 있다.

PF-573228

≥95% (HPLC), FAK inhibitor, powder

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

Quality Level

assay

form

color

solubility

storage temp.

SMILES string

InChI

InChI key

관련 카테고리

설명

Biochem/physiol Actions

Features and Benefits

안전성 정보

pictograms

signalword

hcodes

pcodes

Hazard Classifications

저장 등급

flash_point_f

flash_point_c

문서

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