Q3251
Quinacrine dihydrochloride
≥90% (TLC), powder, MAO-A/B inhibitor
동의어(들):
6-Chloro-9-(4-diethylamino-1-methylbutylamino)-2-methoxyacridine dihydrochloride, Atebrin dihydrochloride, Mepacrine dihydrochloride
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크기 선택
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C23H30ClN3O · 2HCl
CAS 번호:
Molecular Weight:
472.88
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352101
EC Number:
200-700-8
MDL number:
Beilstein/REAXYS Number:
4834013
제품 이름
Quinacrine dihydrochloride, ≥90%
biological source
synthetic
Quality Level
assay
≥90%
form
powder
mp
257 °C
solubility
H2O: soluble, clear to hazy
originator
Bayer
SMILES string
Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13
InChI
1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H
InChI key
UDKVBVICMUEIKS-UHFFFAOYSA-N
Gene Information
human ... MAOA(4128), MAOB(4129)
General description
Quinacrine is an acridine derivative and a potent antimalarial agent.
Application
Quinacrine dihydrochloride has been used:
- in its uptake and accumulation studies in mouse lung slices using fluorescence microscope
- in the staining of ATP vesicles in mesenchymal stem cells (MSCs)
- in uptake-release assay for characterization of dense granule functionality of platelets
Biochem/physiol Actions
Non-selective MAO-A/B inhibitor.
Quinacrine has anthelmintic functionality and used in the female sterilization. It is used to treat systemic lupus erythematosus and rheumatic diseases. Apart from malaria, Quinacrine is effective for treating giardia and tapeworm infections. It inhibits nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in addition to monoamine oxidase inhibition.
Features and Benefits
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Preparation Note
Stock solutions are stable for up to 60 h at 20°C.
Other Notes
This product is not assigned an expiration date or recommended retest date.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
저장 등급
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
관련 콘텐츠
Product Information Sheet
Denise De Zanet et al.
PloS one, 12(9), e0184941-e0184941 (2017-09-19)
A new biosensor for the real-time analysis of thrombus formation is reported. The fast and accurate monitoring of the individual thrombotic risk represents a challenge in cardiovascular diagnostics and in treatment of hemostatic diseases. Thrombus volume, as representative index of
Abnormal differentiation of B cells and megakaryocytes in patients with Roifman syndrome
Heremans J, et al.
The Journal of Allergy and Clinical Immunology, 142(2), 630-646 (2018)
Mayur Nimbadas Devare et al.
Aging cell, 19(6), e13151-e13151 (2020-05-26)
Glucose controls the phosphorylation of silent information regulator 2 (Sir2), a NAD+ -dependent protein deacetylase, which regulates the expression of the ATP-dependent proton pump Pma1 and replicative lifespan (RLS) in yeast. TORC1 signaling, which is a central regulator of cell