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Merck

S006

Ketanserin (+)-tartrate salt

≥97%, 5-HT2 serotonin receptor antagonist, solid

동의어(들):

3-(2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1H,3H)-quinazolinedione (+)-tartrate salt, R 41468 (+)-tartrate salt

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C22H22FN3O3 · C4H6O6
CAS 번호:
Molecular Weight:
545.51
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
281-062-8
MDL number:
Assay:
≥97%
Form:
solid
Quality level:
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제품 이름

Ketanserin (+)-tartrate salt, ≥97%, solid

Quality Level

assay

≥97%

form

solid

color

white

solubility

ethanol: 3 mg/mL, DMSO: 52 mg/mL (lit.)(lit.), 0.1 M HCl: 6 mg/mL (lit.)(lit.)

storage temp.

2-8°C

SMILES string

O[C@H]([C@@H](O)C(O)=O)C(O)=O.Fc1ccc(cc1)C(=O)C2CCN(CC2)CCN3C(=O)Nc4ccccc4C3=O

InChI

1S/C22H22FN3O3.C4H6O6/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1

InChI key

KMTLTEVOQLMYRS-LREBCSMRSA-N

Gene Information

Application

Ketanserin (+)-tartrate salt has been used:
  • as a 5HT2A antagonist in Krebs-Henseleit buffer solution
  • for hormonal treatment to study the effects of exogenous manipulation of different hormonal systems in interaction with parasite infection on client′s behavior
  • to study the behavioural changes of incision pain rats

Biochem/physiol Actions

Selective 5-HT2 serotonin receptor antagonist.
Selective 5-HT2 serotonin receptor antagonist. Ketanserin significantly reduces nicotine self-administration in rats, supporting an unexpected involvement of serotonin in nicotine addiction.
Ketanserin stimulates collagen synthesis and is involved in wound healing.


pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges



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문서 라이브러리 방문



Effects of short-term exposure to ectoparasites on fish cortisol and hematocrit levels
Triki Z, et al.
Marine biology, 163(9), 187-187 (2016)
Ketanserin in wound healing and fibrosis: investigations into its mechanism of action
Serotonin, 12(6), 451-455 (1990)
The 5-HT2A receptor potassium-chloride cotransporter 2 signaling pathway in a rat incision pain model
Dong R, et al.
Experimental and Therapeutic Medicine, 12(6), 3583-3588 (2016)