S0447
SIS3
≥98% (HPLC), TGF-β1/ALK-5 phosphorylation inhibitor, powder
동의어(들):
(2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C28H27N3O3 · HCl
CAS 번호:
Molecular Weight:
489.99
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
SIS3, ≥98% (HPLC), powder
SMILES string
Cl.COc1cc2CCN(Cc2cc1OC)C(=O)\C=C\c3c(-c4ccccc4)n(C)c5ncccc35
InChI key
CDKIEBFIMCSCBB-CALJPSDSSA-N
InChI
1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
H2O: <2 mg/mL
DMSO: >20 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
SIS3 is a novel specific inhibitor of TGF-β1/ALK-5 phosphorylation of Smad3
Sugar insensitive 3 (SIS3) promotes drug-induced apoptosis and hinders the function of adenosine triphosphate (ATP)-binding cassette (ABC) transporter (ABCB1) and ABCG2. It resensitizes ABCB1 and ABCG2 overexpressed in cancerous cells, which contributes to chemotherapeutics.
Application
Sugar insensitive 3 (SIS3) has been used as smad3 inhibitor in various cells.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Ming-Heng Wu et al.
Scientific reports, 7(1), 11006-11006 (2017-09-10)
Concomitant expressions of glycan-binding proteins and their bound glycans regulate many pathophysiologic processes, but this issue has not been addressed in liver fibrosis. Activation of hepatic stellate cells (HSCs) is a rate-limiting step in liver fibrosis and is an important
Karl David Brown et al.
Investigative ophthalmology & visual science, 58(7), 3011-3017 (2017-06-13)
Fibrotic scarring after ocular surgeries and chemical burn injuries can impede clarity of the cornea and cause vision impairment. Transforming growth factor β (TGFβ) signaling pathway is known to mediate fibrotic scarring, and NADPH oxidase-derived reactive oxygen species has been
Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes?But without modulating bone morphogenetic protein 7 signaling
Gressner OA, et al.
Hepatology, 49(6), 2021-2030 (2009)
Transforming growth factor-beta2 utilizes the canonical Smad-signaling pathway to regulate tissue transglutaminase expression in human trabecular meshwork cells
Tovar-Vidales T, et al.
Experimental Eye Research, 93(4), 442-451 (2011)
The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring
Tang PMK, et al.
Kidney International, 93(1), 173-187 (2018)
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