S193
Anti-Synapsin I antibody produced in rabbit
affinity isolated antibody, lyophilized powder
동의어(들):
Anti-EPILX, Anti-MRX50, Anti-SYN1a, Anti-SYN1b, Anti-SYNI
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
polyclonal
Application:
DB, IF, IHC (f), IP, WB
Citations:
36
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
mol wt
antigen ~80 kDa (Synapsin Ia)
species reactivity
rat, mouse, human, bovine
technique(s)
dot blot: 1:1000, immunohistochemistry (frozen sections): 1:2000, immunoprecipitation (IP): 1 μg, indirect immunofluorescence: 1:2000, western blot: 1:1000
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SYN1(6853)
mouse ... Syn1(20964)
rat ... Syn1(24949)
관련 카테고리
General description
Synapsin I (1a and 1b) refers to two nearly identical phosphoproteins found in the cytoplasmic surface of synaptic vesicles of the CNS (central nervous system) and PNS(peripheral nervous system). It may be used to localize and detect synapsin I (synapsins Ia and Ib are collectively referred to as synapsin I) in nerve terminals.The SYN1 gene is mapped to human chromosome Xp11.3-p11.23.
Immunogen
synapsin I from bovine brain.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Rabbit polyclonal anti-Synapsin I antibody can be used for the localization and detection of synapsin I (synapsins Ia and Ib, approximately 80 kDa and 77 kDa, are collectively referred to as synapsin I) in nerve terminals.
- Western Blotting (1 paper)
- immunohistochemistry
- immunoblotting
- immunoprecipitation
- ELISA.
Rabbit polyclonal anti-Synapsin I antibody can be used for the localization and detection of synapsin I (synapsins Ia and Ib, approximately 80 kDa and 77 kDa, are collectively referred to as synapsin I) in nerve terminals.
Biochem/physiol Actions
Synapsin I is involved in the regulation of axonogenesis and synaptogenesis wherein it serves as a substrate of various protein kinases including those activated by cAMP, calciuim/calmodulin, mitogens, and cyclins. The antibody strongly reacts with the synapsin I doublet. Synapsin I is associated with vesicle trafficking. Mutation in this gene is one of the known cause for familial epilepsy and autism spectrum disorders.
Physical form
Lyophilized from ammonium bicarbonate (5 mM)
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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저장 등급
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Synapsin III: role in neuronal plasticity and disease.
Porton B, et al.
Seminars in Cell & Developmental Biology, 22(4), 416-424 (2011)
Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356? mutation in synapsin I.
Giannandrea M, et al.
PLoS ONE, 8(6), e67724-e67724 (2013)
Increased synapsin I expression in cerebral malaria.
Thonsranoi K, et al.
International Journal of Clinical and Experimental Pathology, 8(11), 13996-13996 (2015)
PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders.
Paemka L, et al.
PLoS ONE, 8(12), e80737-e80737 (2013)
DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression.
Cruceanu C, et al.
BMC Psychiatry, 16(1), 286-286 (2016)
관련 콘텐츠
Datasheet
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