S2626
Spermidine
synthetic, ≥99% (GC), neuronal nitric oxide synthase (nNOS) inhibitor, solid or liquid (clear)
동의어(들):
1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
NH2(CH2)3NH(CH2)4NH2
CAS 번호:
Molecular Weight:
145.25
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
204-689-0
MDL number:
Beilstein/REAXYS Number:
1698591
제품 이름
Spermidine, ≥99% (GC)
InChI key
ATHGHQPFGPMSJY-UHFFFAOYSA-N
InChI
1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
SMILES string
NCCCCNCCCN
biological source
synthetic
assay
≥99% (GC)
form
solid or liquid (clear)
impurities
DNase, none detected, RNase, none detected, protease, none detected
refractive index
n20/D 1.479 (lit.)
mp
22-25 °C
solubility
water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
density
0.925 g/mL at 25 °C (lit.)
storage temp.
room temp
Quality Level
Gene Information
rat ... Ppm1a(24666)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
General description
Spermidine, a natural biomolecule, is known for its wide-ranging health benefits, including anti-inflammatory effects, antioxidant properties, and improvements in respiratory function. It carries a positive charge at physiological pH, allowing it to interact with oppositely charged DNA and RNA. Dietary intake of spermidine is associated with a reduced risk of neurodegeneration, metabolic diseases, heart ailments, and cancer. Spermidine-induced autophagy has been shown to slow the rate of cognitive decline by clearing amyloid-beta plaques in the brain. Spermidine supplementation improves mitochondrial metabolism and translational activity. Moreover, spermidine exhibits cell-autonomous effects on cancer cells and influences their communication with immune effectors, leading to the acceleration of tumor-associated antigen identification and cancer cell death. Spermidine-mediated autophagy inhibits the activation of apoptosis in cancer cells and is linked to tissue development and cell differentiation. This natural compound is additionally recognized for its neuroprotective, and anti-aging properties and is naturally found in semen, as well as in various plant sources.
The enzyme nitric oxide synthase (nNOS) is involved in the production of nitric oxide.
Application
Spermidine has been used:
- in the preparation of 5x transcription buffer
- in the treatment of double-stranded RNA along with other reagents to increase the uptake of dsRNA by nematodes
- as a standard in the analytical study of rat brain polyamines (185)
Biochem/physiol Actions
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T4 polynucleotide kinase activity.
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
Other Notes
Store under inert gas. Air sensitive; strongly hygroscopic.
Disclaimer
Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
저장 등급
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
233.6 °F - closed cup
flash_point_c
112 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
Parteek P, et al.
Frontiers in Chemistry, 11, 1164477-1164477 (2023)
Quantitative Detection of Double-Stranded RNA-Mediated Gene Silencing of Parasitism Genes in Heterodera glycines.
Sukno SA
Journal of Nematology, 39(2), 145-152 (2007)
In vitro Reconstitution Assay of miRNA Biogenesis by Arabidopsis DCL1.
Wang T
Bio-protocol, 5(8), e1454-e1454 (2015)
Evidence for the contribution of NOS1 gene polymorphism (rs3782206) to prefrontal function in schizophrenia patients and healthy controls.
Zhang Z
Neuropsychopharmacology, 40(6), 1383-1394 (2015)
Michi Miura et al.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 28(3-4), 381-393 (2020-10-19)
CUT&RUN is a powerful tool to study protein-DNA interactions in vivo. DNA fragments cleaved by the targeted micrococcal nuclease identify the footprints of DNA-binding proteins on the chromatin. We performed CUT&RUN on human lung carcinoma cell line A549 maintained in
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.