S3132
Seleno-L-methionine
≥98% (TLC), powder, IgE expression inhibitor
동의어(들):
(S)-2-Amino-4-(methylseleno)butyric acid
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
CH3SeCH2CH2CH(NH2)CO2H
CAS 번호:
Molecular Weight:
196.11
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
제품 이름
Seleno-L-methionine, ≥98% (TLC), powder
SMILES string
C[Se]CC[C@H](N)C(O)=O
InChI
1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChI key
RJFAYQIBOAGBLC-BYPYZUCNSA-N
assay
≥98% (TLC)
form
powder
color
white to off-white
solubility
H2O: 50 mg/mL
storage temp.
−20°C
Quality Level
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관련 카테고리
General description
Seleno-L-Methionine (SeMet), an organic form of selenium is found in Cupriavidus metallidurans.
Application
Seleno-L-methionine has been used:
- in toxicity studies in Japanese Medaka embryos
- to study its effects on selenium status indicators in pregnant long-tailed macaques (Macaca Fascicularis)
- to label proteins for single wavelength anomalous dispersion (SAD) phasing
Seleno-L-methionine has been used:
- as a nonchemical stressor to treat Japanese Medaka fish embryos
- to label proteins for Single wavelength Anomalous Dispersion (SAD) phasing
- to study the distribution and inhibition effects of seleno-L-methionine on 4T1 mouse mammary carcinoma
Biochem/physiol Actions
Seleno-L-Methionine (SeMet) is capable of repressing atopic dermatitis (AD)-like skin lesions. It can also prevent the expression of total immunoglobulin E (IgE) and interleukin 4 (IL-4). It can cause ecotoxicity as it is absorbed by fish through diet.
Seleno-L-methionine displays antioxidant activity and has been shown to increase the activity of glutathione peroxidase in endothelial cells. Glutathione peroxidase protects cells from oxidative damage, such as DNA strand breaks, mutations and interference with protein tyrosine-based signaling and other protein functions due to formation of 3-nitrotyrosine, caused by excessive peroxynitrite. Seleno-L-methionine administration to cancer cell lines (MCF-7/S breast carcinoma, DU-145 prostate cancer cells and UACC-375 melanoma) results in apoptotic cell death and aberrant mitosis. These human tumor cell lines exhibited dose-dependent growth inhibition by selenomethionine in the micromolar range (45 to 130μM), while growth inhibition of normal fibroblasts required 1mM selenomethionine.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
저장 등급
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
250.3 - 346.3 °F
flash_point_c
121.3 - 174.6 °C
Distribution and inhibition effect of Seleno-L-Methionine on 4T1 mouse mammary carcinoma.
Song H
International Journal of Physiology, Pathophysiology and Pharmacology, 7(2), 76-86 (2015)
C Redman et al.
Cancer letters, 125(1-2), 103-110 (1998-05-05)
Selenium supplementation has been shown for many years to work as an anticarcinogenic agent both in epidemiology and in in vitro studies. Selenium supplementation has recently been shown to decrease total cancer incidence. However, the mechanism of action of selenium
Application of linker technique to trap transiently interacting protein complexes for structural studies.
Reddy Chichili VP
Journal of biomechanics, 3(1), e34-e34 (2016)
Arka Chakraborty et al.
Nucleic acids research, 45(2), 951-967 (2016-12-03)
The mitochondrial genome (mtDNA) is assembled into nucleo-protein structures termed nucleoids and maintained differently compared to nuclear DNA, the involved molecular basis remaining poorly understood. In yeast (Saccharomyces cerevisiae), mtDNA is a ∼80 kbp linear molecule and Abf2p, a double
Seleno-L-methionine is the predominant organic form of selenium in Cupriavidus metallidurans CH34 exposed to selenite or selenate
Avoscan L, et al.
Applied and Environmental Microbiology, 72(9), 6414-6416 (2006)
문서
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
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