S5768
Monoclonal Anti-Synaptophysin antibody produced in mouse
clone SVP-38, ascites fluid
동의어(들):
Synaptophysin Antibody, Synaptophysin Antibody - Monoclonal Anti-Synaptophysin antibody produced in mouse
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
SVP-38, monoclonal
Application:
ELISA (i), IHC (f), IHC (p), WB
Citations:
306
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
SVP-38, monoclonal
mol wt
antigen 38 kDa
contains
15 mM sodium azide
species reactivity
pig, rat, human, guinea pig
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunohistochemistry (frozen sections): 1:200 using rat cerebellum, indirect ELISA: suitable, western blot: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SYP(6855)
rat ... Syp(24804)
General description
Synaptophysin (SYP) is an integral membrane glycoprotein of 38,000 Da and it has four membrane-spanning domains. Synaptophysin is localized to neurons, neuromuscular junctions, paraganglia cells, hypophysis, pancreatic islet cells, and adrenal cells. SYP gene is mapped to human chromosome Xp11.23. Monoclonal Anti-Synaptophysin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
Immunogen
Rat retina synaptosome.
Application
Monoclonal Anti-Synaptophysin antibody has been used in western blotting.
Biochem/physiol Actions
Labels synaptophysin in neurons, neuromuscular junctions, benign and malignant neural tumors, paraganglia cells, hypophysis, pancreatic islet cells, and adrenal cells.
Synaptophysin participates in calcium dependent exocytosis. The antibody detects synaptophysin in many types of benign and malignant neural and epithelial neuroendocrine neoplasms. It is widely used as a potential marker to study the circulation of synapses in the brain and to discover the basic features of the life cycle of synaptic vesicles (SVs).
Physical form
Monoclonal Anti-Synaptophysin is provided as ascites fluid containing 0.1% sodium azide.
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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저장 등급
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Synaptophysin: a marker protein for neuroendocrine cells and neoplasms.
Wiedenmann B, et al.
Proceedings of the National Academy of Sciences of the USA, 83(10), 3500-3504 (1986)
CD200 fusion protein decreases microglial activation in the hippocampus of aged rats.
Cox FF, et al.
Brain, behavior, and immunity, 26(5), 789-796 (2012)
The distribution of synapsin I and synaptophysin in hippocampal neurons developing in culture.
Fletcher TL, et al.
The Journal of Neuroscience, 11(6), 1617-1626 (1991)
BDNF-induced synaptic delivery of AMPAR subunits is differentially dependent on NMDA receptors and requires ERK.
Li W and Keifer J
Neurobiology of Learning and Memory, 91(3), 243-249 (2009)
Construction of two YAC contigs in human Xp11. 23?p11. 22, one encompassing the loci OATL1, GATA, TFE3, and SYP, the other linking DXS255 to DXS146.
Fisher SE, et al.
Genomics, 29(2), 496-502 (1995)
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