S7900
Saponin from quillaja bark
Sapogenin content ≥10 %
SMILES string
O1[C@H]([C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O)O[C@H]2[C@@H](O[C@@H]([C@H]([C@@H]2O)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)CO)C(=O)O)O[C@@H]3[C@@](C4[C@@](C5[C@]([C@@]6(C[C@H]([C@]7([C@H]([C@@H](C(CC7C6=CC5)(C)C)OC(=O)\C(=C/C)\C)OC(=O)C)CO)O)C)(CC4)C)(CC3)C
InChI key
AXNVHPCVMSNXNP-ZELRDNAQSA-N
description
non-ionic
composition
Sapogenin content, ≥10%
technique(s)
HPLC: suitable, protein quantification: suitable
sulfated ash
<20%
Quality Level
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Application
Saponin from Quillaja bark has been used:
- to stain CD4+ and CD8+ T-cells
- to lyse trophozoite-infected red blood cells
- in immunohistochemical staining
Biochem/physiol Actions
Potent hemolytic when injected i.v.; surfactant that enhances penetration of proteins and other macromolecules through cell membranes; it also has been used as an adjuvant for vaccines.
Saponins are associated with many biological and pharmacological activities. It is known to stimulate immune response in mammals. Hence it is used as vaccine adjuvants. Saponins possesses antiviral, antifungal, antitumor, anti-inflammatory, hypoglycemic and hypocholesterolemic effects.
Saponins solubilize the low density lipoprotein (LDL) fraction of cholesterol in micelles, thus lowering their concentration. Saponin from Quillaja bark is used as a flavoring agent in food and beverages. This saponin has been shown to enhance immune-cell proliferation in vitro.
General description
Saponins are natural steroidal glycoside (terpenes).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - STOT SE 3
target_organs
Respiratory system
저장 등급
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Adjuvant effects of saponins on animal immune responses.
Rajput ZI
Journal of Zhejiang University. Science. B, 8(3), 153-161 (2007)
Xiaogang Jiang et al.
Environmental pollution (Barking, Essex : 1987), 236, 416-424 (2018-02-08)
Saponin-rich extracts from Quillaja saponaria and Chenopodium quinoa have been registered by US EPA as active ingredients in biopesticides, and extract from tea seed powder, Camellia oleifera has been proposed for biocidal use. If saponin-rich biopesticides are efficient against pests
Induction of human papillomavirus-specific CD4(+) and CD8(+) lymphocytes by E7-pulsed autologous dendritic cells in patients with human papillomavirus type 16- and 18-positive cervical cancer.
Santin AD
Journal of Virology, 73(7), 5402-5410 (1999)
Natalie J Spillman et al.
Molecular and biochemical parasitology, 162(1), 96-99 (2008-08-05)
The intraerythrocytic malaria parasite, Plasmodium falciparum maintains an intracellular pH (pH(i)) of around 7.3. If subjected to an experimentally imposed acidification the parasite extrudes H(+), thereby undergoing a pH(i) recovery. In a recent study, Bennett et al. [Bennett TN, Patel
Effect of testosterone on insulin stimulated IRS1 Ser phosphorylation in primary rat myotubes--a potential model for PCOS-related insulin resistance.
Allemand MC
PLoS ONE, 4(1), e4274-e4274 (2009)
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