S8809
Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse
~1 mg/mL, clone K58/35, purified immunoglobulin
동의어(들):
Sodium Channel Antibody
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
K58/35, monoclonal
Application:
IF, IHC (f), WB
Citations:
122
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
K58/35, monoclonal
species reactivity
mammals
concentration
~1 mg/mL
technique(s)
immunohistochemistry (frozen sections): suitable, indirect immunofluorescence: 1 μg/mL using sciatic and optic nerve sections; cultured hypocampal neurons, western blot: 1 μg/mL using crude brain membrane prep (rat)
isotype
IgG1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN8A(6334), SCN9A(6335)
mouse ... Scn10a(20264), Scn11a(24046), Scn1a(20265), Scn3a(20269), Scn4a(110880), Scn5a(20271), Scn8a(20273), Scn9a(20274)
rat ... Scn10a(29571), Scn11a(29701), Scn1a(81574), Scn3a(497770), Scn4a(25722), Scn5a(25665), Scn8a(29710), Scn9a(78956)
General description
Voltage-gated sodium channels/VGSCs (Nav) are transmembrane proteins that are initiated by the depolarization of the membrane. They are heteromultimers with large pore-forming α-subunits and smaller β-subunits.
Immunogen
synthetic peptide CTEEQKKYYNAMKKLGSKK from the intracellular III-IV loop of Na+ channels
Application
Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse has been used in:
- immunohistochemistry(1:50)
- immunostaining (1:200)
- immunofluorescence
- immunocytochemistry (1:100)
Biochem/physiol Actions
The sequence recognized by this clone is identical in all known vertebrate Na+ channels. In cultured hippocampal neurons, the antibody specifically stains the axon initial segment. In sciatic and optic nerves, it stains the nodes of Ranvier.
Voltage-gated sodium channels/VGSCs (Nav) participates in nociceptive transmission. They play a key role in regulating the exchange between the extracellular and intracellular spaces. VGSCs are crucial for the initiation and firing of action potentials. They participate in neuronal excitability. Hence mutations in the VGSC genes results in several epileptic disorders.
Physical form
Solution in 10 mM Tris, pH 7.5, containing 0.1 m NaCl, 30% glycerol, and 15 mM sodium azide.
Legal Information
Sold under exclusive license from SUNY Stony Brook.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Amanda L York et al.
eNeuro, 4(4) (2017-08-12)
The neuromuscular junction (NMJ) is a chemical synapse formed between motoneurons and skeletal muscle fibers. The vertebrate NMJ uses acetylcholine (ACh) as the neurotransmitter and features numerous invaginations of the postsynaptic muscle membrane termed junctional folds. ACh receptors (AChRs) are
Analgesic and antipyretic natural products
Shilpi JA and Uddin SJ
Annual Reports in Medicinal Chemistry, 55, 435-458 (2020)
Elisa D'Este et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(2), E191-E199 (2016-12-23)
We used stimulated emission depletion (STED) superresolution microscopy to analyze the nanoscale organization of 12 glial and axonal proteins at the nodes of Ranvier of teased sciatic nerve fibers. Cytoskeletal proteins of the axon (betaIV spectrin, ankyrin G) exhibit a
Jennifer Koenig et al.
PloS one, 10(6), e0128830-e0128830 (2015-06-04)
The Nav1.7 voltage-gated sodium channel, encoded by SCN9A, is critical for human pain perception yet the transcriptional and post-transcriptional mechanisms that regulate this gene are still incompletely understood. Here, we describe a novel natural antisense transcript (NAT) for SCN9A that
J-C Platel et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(52), 19174-19179 (2005-12-17)
Before synaptogenesis, early excitability implicating voltage-dependent and transmitter-activated channels is known to be crucial for neuronal development. We previously showed that preplate (PP) neurons of the mouse neocortex express functional Na(+) channels as early as embryonic day 12. In this
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