S8809

Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse

Name: Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse
Brand: SIGMA

~1 mg/mL, clone K58/35, purified immunoglobulin

동의어(들):

Sodium Channel Antibody

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02097413

주요 문서

모든 문서 보기

기술 서비스

도움이 필요하신가요? 저희 숙련된 과학자 팀이 도와드리겠습니다.

도움 문의

기술 서비스

도움이 필요하신가요? 저희 숙련된 과학자 팀이 도와드리겠습니다.

도움 문의

제품 이름

Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse, ~1 mg/mL, clone K58/35, purified immunoglobulin

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

K58/35, monoclonal

species reactivity

mammals

concentration

~1 mg/mL

technique(s)

immunohistochemistry (frozen sections): suitable
indirect immunofluorescence: 1 μg/mL using sciatic and optic nerve sections; cultured hypocampal neurons
western blot: 1 μg/mL using crude brain membrane prep (rat)

isotype

IgG1

UniProt accession no.

P35498

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Voltage-gated sodium channels/VGSCs (Nav) are transmembrane proteins that are initiated by the depolarization of the membrane. They are heteromultimers with large pore-forming α-subunits and smaller β-subunits.

Immunogen

synthetic peptide CTEEQKKYYNAMKKLGSKK from the intracellular III-IV loop of Na⁺ channels

Legal Information

Sold under exclusive license from SUNY Stony Brook.

Physical form

Solution in 10 mM Tris, pH 7.5, containing 0.1 m NaCl, 30% glycerol, and 15 mM sodium azide.

Application

Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse has been used in:

immunohistochemistry(1:50)
immunostaining (1:200)
immunofluorescence
immunocytochemistry (1:100)

Biochem/physiol Actions

The sequence recognized by this clone is identical in all known vertebrate Na⁺ channels. In cultured hippocampal neurons, the antibody specifically stains the axon initial segment. In sciatic and optic nerves, it stains the nodes of Ranvier.

Voltage-gated sodium channels/VGSCs (Nav) participates in nociceptive transmission. They play a key role in regulating the exchange between the extracellular and intracellular spaces. VGSCs are crucial for the initiation and firing of action potentials. They participate in neuronal excitability. Hence mutations in the VGSC genes results in several epileptic disorders.

적합한 제품을 찾을 수 없으신가요?

당사의 제품 선택기 도구.을(를) 시도해 보세요.

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Ultrastructural anatomy of nodes of Ranvier in the peripheral nervous system as revealed by STED microscopy.

Elisa D'Este et al.

Proceedings of the National Academy of Sciences of the United States of America, 114(2), E191-E199 (2016-12-23)

We used stimulated emission depletion (STED) superresolution microscopy to analyze the nanoscale organization of 12 glial and axonal proteins at the nodes of Ranvier of teased sciatic nerve fibers. Cytoskeletal proteins of the axon (betaIV spectrin, ankyrin G) exhibit a

Super-Resolution Microscopy Reveals a Nanoscale Organization of Acetylcholine Receptors for Trans-Synaptic Alignment at Neuromuscular Synapses.

Amanda L York et al.

eNeuro, 4(4) (2017-08-12)

The neuromuscular junction (NMJ) is a chemical synapse formed between motoneurons and skeletal muscle fibers. The vertebrate NMJ uses acetylcholine (ACh) as the neurotransmitter and features numerous invaginations of the postsynaptic muscle membrane termed junctional folds. ACh receptors (AChRs) are

Analgesic and antipyretic natural products

Shilpi JA and Uddin SJ

Annual Reports in Medicinal Chemistry, 55, 435-458 (2020)

Na+ channel-mediated Ca2+ entry leads to glutamate secretion in mouse neocortical preplate.

J-C Platel et al.

Proceedings of the National Academy of Sciences of the United States of America, 102(52), 19174-19179 (2005-12-17)

Before synaptogenesis, early excitability implicating voltage-dependent and transmitter-activated channels is known to be crucial for neuronal development. We previously showed that preplate (PP) neurons of the mouse neocortex express functional Na(+) channels as early as embryonic day 12. In this

Developmental changes in diffusion anisotropy coincide with immature oligodendrocyte progression and maturation of compound action potential.

Alexander Drobyshevsky et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(25), 5988-5997 (2005-06-25)

Disruption of oligodendrocyte lineage progression is implicated in the white-matter injury that occurs in cerebral palsy. We have previously published a model in rabbits consistent with cerebral palsy. Little is known of normal white-matter development in perinatal rabbits. Using a

모든 관련된 서류 보기

Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse

~1 mg/mL, clone K58/35, purified immunoglobulin

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

biological source

conjugate

antibody form

antibody product type

clone

species reactivity

concentration

technique(s)

isotype

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Quality Level

Gene Information

설명

Disclaimer

General description

Immunogen

Legal Information

Physical form

Application

Biochem/physiol Actions

문서

시험 성적서(COA)

이 제품을 이미 가지고 계십니까?

관련 참고 논문

관련 참고 프로토콜

관련 콘텐츠

기술 서비스