S9549
Superoxide dismutase–polyethylene glycol from bovine erythrocytes
lyophilized powder, ≥1,350 units/mg protein
동의어(들):
PEG-SOD
General description
Superoxide dismutase from bovine erythrocytes is a copper and zinc superoxide dismutase. Copper and zinc ions are coordinated by active site histidine residues. It has β-barrel structure.
Application
Superoxide dismutase-polyethylene glycol from bovine erythrocytes has been used:
- in the incubation of lung slices for measurement of dihydroethidium (DHE) fluorescence in cultured bovine pulmonary artery endothelial cells
- as supplement in T cell culture to investigate its effect on cytokine production
- in the preincubation of the carotid artery sections prior to DHE treatment
Biochem/physiol Actions
Superoxide dismutase-polyethylene glycol (SOD-PEG) is effective than SOD in scavenging free radicals in injuries. It reduces oxidative damage in ovarian follicles cell culture and during ovarian tissue transplantation. SOD-PEG is also effective in scavenging superoxide in mitochondrial abnormalities.
Packaging
Package size based on protein content
Physical form
Lyophilized powder containing PEG plus 5% citrate buffer salts
Preparation Note
Enzyme derived
Other Notes
Superoxide dismutase from bovine erythrocytes coupled to methoxy-polyethylene glycol, M.W. 5,000, through secondary amine linkage.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Roles of zinc and copper in modulating the oxidative refolding of bovine copper, zinc superoxide dismutase
Li HT, et al.
Acta biochimica et biophysica Sinica, 42(3), 183-194 (2010)
Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity.
Yi X, Yuan D, Farr SA, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 191, 34-46 (2014)
Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia
Dayal S, et al.
PLoS ONE, 12(4), e0175732-e0175732 (2017)
Lingli Li et al.
Kidney international, 92(3), 625-633 (2017-04-12)
Myogenic contractions protect kidneys from barotrauma but are impaired in chronic kidney disease (CKD). Since myogenic contractions are enhanced by superoxide but impaired by hydrogen peroxide, we tested the hypothesis that they are counterregulated by superoxide and H2O2 from NOX2/p47phox and/or
The beneficial effects of polyethylene glycol-superoxide dismutase on ovarian tissue culture and transplantation
Kim EJ, et al.
Journal of Assisted Reproduction and Genetics, 32(10), 1561-1569 (2015)
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