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Merck

SBR00068

Streptomycin

Ready Made Solution, 100 mg/mL in water

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제품정보 (DICE 배송 시 비용 별도)

CAS 번호:
3810-74-0
UNSPSC Code:
51281624
NACRES:
NA.76

주요 문서

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SMILES string

[S](=O)(=O)(O)O.[S](=O)(=O)(O)O.[S](=O)(=O)(O)O.N([C@@H]4[C@@H](O[C@H]([C@@H]([C@H]4O)O)CO)O[C@H]5[C@@H](O[C@H]([C@]5(O)C=O)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H]([C@@H]6O)O)N=C(N)N)O)N=C(N)N)C.N([C@@H]1[C@@H](O[C@H]([C@@H]([C@H]1O)O)CO)O[C@H]2[C@@H](O[C@H]([

InChI key

QTENRWWVYAAPBI-YZTFXSNBSA-N

InChI

1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-

Quality Level

200

form

liquid, ready-to-use solution

specific activity

(Antibacterial)

concentration

100 mg/mL in water

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria

mode of action

protein synthesis | interferes

storage temp.

−20°C

관련 카테고리

General description

Chemical structure: aminoglycoside

Application

Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50 μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.

Biochem/physiol Actions

Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.

Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.

Antimicrobial spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.

Preparation Note

  • Streptomycin ready made solution contains 100 mg/mL streptomycin sulfate in water.
  • Streptomycin: sulfate salt ratio is 1:1.5.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361fd

Hazard Classifications

Repr. 2

저장 등급

10 - Combustible liquids

wgk

WGK 3

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시험 성적서(COA)

Lot/Batch Number
0000490053
0000490053
0000490052
0000490052
0000375906

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