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Merck

SML0108

R18 trifluoroacetate

≥98% (HPLC)

동의어(들):

L-Prolyl-L-histidyl-L-cysteinyl-L-valyl-L-prolyl-L-arginyl-L-a-aspartyl-L-leucyl-L-seryl-L-tryptophyl-L-leucyl-L-a-aspartyl-L-leucyl-L-a-glutamyl-L-alanyl-L-asparaginyl-L-methionyl-L-cysteinyl-L-leucyl-L-proline trifluoroacetate, PHCVPRDLSWLDLEANMCLP trifluoroacetate, Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro trifluoroacetate

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C101H157N27O29S3
CAS 번호:
211364-78-2
Molecular Weight:
2309.69
NACRES:
NA.25
PubChem Substance ID:
329825163
UNSPSC Code:
12352200
MDL number:
MFCD20527319

주요 문서

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InChI

1S/C101H157N27O29S3.C2HF3O2/c1-48(2)33-62(86(142)111-60(25-26-77(131)132)83(139)110-53(11)81(137)114-67(39-76(102)130)91(147)112-61(27-32-160-12)85(141)124-72(45-158)95(151)122-70(36-51(7)8)98(154)128-31-18-24-75(128)100(156)157)116-93(149)69(41-79(135)136)121-87(143)63(34-49(3)4)115-89(145)65(37-54-42-108-57-20-14-13-19-56(54)57)118-94(150)71(44-129)123-88(144)64(35-50(5)6)117-92(148)68(40-78(133)134)120-84(140)59(22-16-29-107-101(103)104)113-97(153)74-23-17-30-127(74)99(155)80(52(9)10)126-96(152)73(46-159)125-90(146)66(38-55-43-105-47-109-55)119-82(138)58-21-15-28-106-58;3-2(4,5)1(6)7/h13-14,19-20,42-43,47-53,58-75,80,106,108,129,158-159H,15-18,21-41,44-46H2,1-12H3,(H2,102,130)(H,105,109)(H,110,139)(H,111,142)(H,112,147)(H,113,153)(H,114,137)(H,115,145)(H,116,149)(H,117,148)(H,118,150)(H,119,138)(H,120,140)(H,121,143)(H,122,151)(H,123,144)(H,124,141)(H,125,146)(H,126,152)(H,131,132)(H,133,134)(H,135,136)(H,156,157)(H4,103,104,107);(H,6,7)/t53-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,80-;/m0./s1

SMILES string

OC(=O)C(F)(F)F.CSCC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@@H]5CCCN5)C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N6CCC[C@H]6C(O)=O

InChI key

RLMYFUMCZYJMNX-KIXMOXNVSA-N

assay

≥98% (HPLC)

form

powder

color

white to off-white

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

관련 카테고리

General description

R18 trifluoroacetate is a nonphosphorylated peptide. This peptide was originally identified as a high-affinity 14-3-3 ligand by phage display.

Application

R18 trifluoroacetate has been used to treat 12-d-old or 14-d-old Super:C-repeat-binding factors (CBFs)-Myc plants for CBF protein immunoblots to study the effect of R18 on CBF3 degradation in planta.

Biochem/physiol Actions

C-repeat-binding factors (CBFs) protein -Myc transgenic plants, R18 is capable of reducing the degradation of CBF1 and CBF3.
R18 (PHCVPRDLSWLDLEANMCLP), a competitive inhibitor of 14-3-3 scaffolding proteins, may be used to study the roles and functions of 14-3-3 scaffolding proteins in cell signaling pathways involved in processes such as apoptosis, division, migration, stress response, and malignant transformation.
R18 is a competitive inhibitor of the 14-3-3 scaffolding proteins. It binds to the general binding groove of 14-3-3. R18 blocks 14-3-3 interaction with most or all of its client proteins.
R18 trifluoroacetate is a competitive inhibitor of the 14-3-3 scaffolding proteins

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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시험 성적서(COA)

Lot/Batch Number
0000417559
0000417559
0000231307
0000231307
0000163948

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Plasma membrane CRPK1-mediated phosphorylation of 14-3-3 proteins induces their nuclear import to fine-tune CBF signaling during cold response
Liu Z, et al.
Molecular Cell, 66(1), 117-128 (2017)
14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove
Petosa C, et al.
The Journal of biological chemistry, 273(26), 16305-16310 (1998)
14-3-3 Dimers Probe the Assembly Status of Multimeric Membrane Proteins
Yuan H, et al.
Current Biology, 13(8), 638-646 (2003)
Carol Mackintosh
The Biochemical journal, 381(Pt 2), 329-342 (2004-05-29)
14-3-3 proteins exert an extraordinarily widespread influence on cellular processes in all eukaryotes. They operate by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. In these
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Science advances, 6(1), eaax5819-eaax5819 (2020-01-09)
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