SML0235
CDPPB
≥98% (HPLC)
동의어(들):
3-Cyano-N-1,3-diphenyl-1H-pyrazol-5-yl)benzamide
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C23H16N4O
CAS 번호:
Molecular Weight:
364.40
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
SMILES string
O.O=C(Nc1cc(nn1-c2ccccc2)-c3ccccc3)c4cccc(c4)C#N
InChI
1S/C23H16N4O.H2O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20;/h1-15H,(H,25,28);1H2
InChI key
GZHZEGYXLNXEBV-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: ≥5 mg/mL at warmed to 60 °C
storage temp.
2-8°C
Quality Level
Application
CDPPB may be used in mGluR5-mediated cell signaling studies.
Biochem/physiol Actions
Activation of metabotropic glutamate 5 receptor by CDPPB enhances the function of NMDA receptor and markers of neuronal plasticity. This improves recognition memory and cognition deficits in schizophrenia.
CDPPB is a glutamate metabotropic mGluR5 positive allosteric modulator.
CDPPB is an mGluR5 positive allosteric modulator
Features and Benefits
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Jason M Uslaner et al.
Neuropharmacology, 57(5-6), 531-538 (2009-07-25)
In the search for strategies to treat schizophrenia, attention has focused on enhancing NMDA receptor function. In vitro experiments show that metabotropic glutamate 5 receptor (mGluR5) activation enhances NMDA receptor activity, and in vivo experiments indicate that mGluR5 positive allosteric
Christina Gobin et al.
Psychopharmacology, 237(1), 115-125 (2019-08-26)
Cocaine use disorder (CUD) remains difficult to treat with no FDA-approved medications to reduce relapse. Antagonism of metabotropic glutamate receptor 5 (mGlu5) has been demonstrated to decrease cocaine-seeking but may also further compromise cognitive function in long-term cocaine users. Here we
Hyejin Lee et al.
PLoS biology, 17(6), e2005326-e2005326 (2019-06-06)
Netrin-G ligand-3 (NGL-3) is a postsynaptic adhesion molecule known to directly interact with the excitatory postsynaptic scaffolding protein postsynaptic density-95 (PSD-95) and trans-synaptically with leukocyte common antigen-related (LAR) family receptor tyrosine phosphatases to regulate presynaptic differentiation. Although NGL-3 has been
Patrick K McCamphill et al.
Science translational medicine, 12(544) (2020-05-22)
Fragile X syndrome is caused by FMR1 gene silencing and loss of the encoded fragile X mental retardation protein (FMRP), which binds to mRNA and regulates translation. Studies in the Fmr1-/y mouse model of fragile X syndrome indicate that aberrant
J G Doria et al.
British journal of pharmacology, 169(4), 909-921 (2013-03-16)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin protein. We have previously demonstrated that the cell signalling of the metabotropic glutamate receptor 5 (mGluR5) is altered in a mouse model of
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