SML0309

Sodium phenylbutyrate

Name: Sodium phenylbutyrate
Brand: SIGMA

≥98% (HPLC), histone deacetylase inhibitor, powder

동의어(들):

4-PBA, 4-Phenylbutyric acid, 4-phenylbutyrate, Buphenyl, Sodium 4-phenylbutyrate, TriButyrate

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₀H₁₁NaO₂

CAS 번호:

1716-12-7

Molecular Weight:

186.18

UNSPSC Code:

12352200

PubChem Substance ID:

329825314

NACRES:

NA.77

MDL number:

MFCD00800247

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

주요 문서

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제품 이름

Sodium phenylbutyrate, ≥98% (HPLC)

SMILES string

[Na+].[O-]C(=O)CCCc1ccccc1

InChI key

VPZRWNZGLKXFOE-UHFFFAOYSA-M

InChI

1S/C10H12O2.Na/c11-10(12)8-4-7-9-5-2-1-3-6-9;/h1-3,5-6H,4,7-8H2,(H,11,12);/q;+1/p-1

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H₂O: ≥5 mg/mL

storage temp.

room temp

Quality Level

100

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Biochem/physiol Actions

Sodium phenylbutyrate is a histone deacetylase inhibitor.

Application

Sodium phenylbutyrate has been used as an endoplasmic reticulum (ER) stress inhibitor to study the role of ER stress in the expression of betatrophin.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

General description

Sodium phenylbutyrate stimulates urinary nitrogen excretion. It is a prodrug, which undergoes β-oxidation to phenylacetate. Sodium phenylbutyrate is used to treat urea cycle disorder. It might be associated with menstrual dysfunction, amenorrhea and painful mucositis of the esophagus and stomach.

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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시험 성적서(COA)

Lot/Batch Number

0000483791

0000440004

0000385496

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies

Lee YH, et al.

Scientific Reports, 6(3), 24013-24013 (2016)

Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control

Lee B, et al.

Molecular Genetics and Metabolism, 100(3), 221-228 (2010)

Advances in Clinical Chemistry, Volume 17 (2014)

The Molecular and Genetic Basis of Neurologic and Psychiatric Disease (2008)

TLR2/4-mediated NF-κB pathway combined with the histone modification regulates β-defensins and interleukins expression by sodium phenyl butyrate in porcine intestinal epithelial cells.

Xiujing Dou et al.

Food & nutrition research, 62 (2018-12-24)

Host defense peptides (HDPs) possess direct antibacterial, antineoplastic, and immunomodulatory abilities, playing a vital role in innate immunity. Dietary-regulated HDP holds immense potential as a novel pathway for preventing infection. In this study, we examined the regulation mechanism of HDPs

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문서

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Sodium phenylbutyrate

≥98% (HPLC), histone deacetylase inhibitor, powder

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

SMILES string

InChI key

InChI

assay

form

color

solubility

storage temp.

Quality Level

관련 카테고리

설명

Biochem/physiol Actions

Application

Features and Benefits

General description

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

문서

시험 성적서(COA)

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