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Merck

SML0560

BRACO19 hydrochloride

≥96% (HPLC), powder, telomerase inhibitor

동의어(들):

N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) hydrochloride

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C35H43N7O2 · xHCl
CAS 번호:
1177798-88-7
Molecular Weight:
593.76 (free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329825553
NACRES:
NA.77
MDL number:
MFCD23380200

주요 문서

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제품 이름

BRACO19 hydrochloride, ≥96% (HPLC)

SMILES string

Cl.Cl.Cl.CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc5cc(NC(=O)CCN6CCCC6)ccc25)cc1

InChI key

MJAPNWJRLLDPAB-UHFFFAOYSA-N

InChI

1S/C35H43N7O2.3ClH/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42;;;/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39);3*1H

assay

≥96% (HPLC)

form

powder

storage condition

desiccated

color

yellow to brown

solubility

H2O: 5 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

관련 카테고리

Biochem/physiol Actions

BRACO19 is a telomerase inhibitor that stabilizes G-quadruplexes, targeting telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest.
BRACO19 stabilizes G-quadruplexes; telomerase inhibitor.
Telomerase is associated with tumor progression and is highly expressed in a number of tumors. BRACO19 is known to prevent the capping and catalytic action of telomerase and thus, might serve as an effective therapeutic approach for cancer treatment. BRACO19 establishes antiviral activity against HIV (human immunodeficiency virus).

Application

BRACO19 hydrochloride has been used to study the role of antiviral activity of G4-stabilizing agents in cells infected with latent human immunodeficiency virus -1 (HIV-1).

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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시험 성적서(COA)

Lot/Batch Number
0000195991
0000154844
0000154843
0000154844

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Yu-Lun Chen et al.
The Chinese journal of physiology, 59(6), 331-347 (2016-11-07)
Lung resistance-related protein (LRP) is a human major vault protein (MVP) implicated in drug resistance of cancer cells in a cell-type dependent manner. The primary goal of the study was to understand the role(s) of LRP in doxorubicin (DOX) resistance
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.
Burger A M, et al.
Cancer Research, 65(4), 1489-1496 (2005)
Deficiency in DNA damage response, a new characteristic of cells infected with latent HIV-1.
Piekna-Przybylska D, et al.
Cell Cycle, 16(10), 968-978 (2017)
Anti-HIV-1 activity of the G-quadruplex ligand BRACO-19.
Perrone R, et al.
The Journal of Antimicrobial Chemotherapy, 69(12), 3248-3258 (2014)
Shyam Sushama Jose et al.
Frontiers in genetics, 9, 345-345 (2018-09-14)
Telomeropathies are rare disorders associated with impaired telomere length control mechanisms that frequently result from genetic mutations in the telomerase complex. Dyskeratosis congenita is a congenital progressive telomeropathy in which mutation in the telomerase RNA component (TERC) impairs telomere maintenance

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