SML0564

PD153035 hydrochloride

Name: PD153035 hydrochloride
Brand: SIGMA

≥98% (HPLC)

동의어(들):

4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride, AG 1517, PD 153035, SU 5271, ZM 252868

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₆H₁₄BrN₃O₂ · HCl

CAS 번호:

183322-45-4

Molecular Weight:

396.67

NACRES:

NA.77

PubChem Substance ID:

329825555

UNSPSC Code:

51111800

MDL number:

MFCD01074805

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

주요 문서

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도움 문의

InChI

1S/C16H14BrN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H

SMILES string

Cl.COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC

InChI key

ZJOKWAWPAPMNIM-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

PD153035 is an EGFR tyrosine kinase inhibitor.

PD153035 is apotent and selective ATP competitive inhibitor of the epidermal growth factor receptor tyrosine kinase EGFR.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

GHS06,GHS05

signalword

Danger

hcodes

H301,H315,H318,H335

pcodes

P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Reduced annexin A6 expression promotes the degradation of activated epidermal growth factor receptor and sensitizes invasive breast cancer cells to EGFR-targeted tyrosine kinase inhibitors.

Rainelli B Koumangoye et al.

Molecular cancer, 12(1), 167-167 (2013-12-21)

The expression of annexin A6 (AnxA6) in AnxA6-deficient non-invasive tumor cells has been shown to terminate epidermal growth factor receptor (EGFR) activation and downstream signaling. However, as a scaffolding protein, AnxA6 may stabilize activated cell-surface receptors to promote cellular processes

N‑glycosylation and receptor tyrosine kinase signaling affect claudin‑3 levels in colorectal cancer cells.

Amelia G Pérez et al.

Oncology reports, 44(4), 1649-1661 (2020-09-19)

Changes in protein levels in different components of the apical junctional complex occur in colorectal cancer (CRC). Claudin‑3 is one of the main constituents of tight junctions, and its overexpression can increase the paracellular flux of macromolecules, as well as

ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization.

Naoya Hino et al.

Developmental cell, 53(6), 646-660 (2020-06-05)

During collective migration of epithelial cells, the migration direction is aligned over a tissue-scale expanse. Although the collective cell migration is known to be directed by mechanical forces transmitted via cell-cell junctions, it remains elusive how the intercellular force transmission

Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation.

P Dhawan et al.

Oncogene, 30(29), 3234-3247 (2011-03-09)

Claudin-2 is a unique member of the claudin family of transmembrane proteins, as its expression is restricted to the leaky epithelium in vivo and correlates with epithelial leakiness in vitro. However, recent evidence suggests potential functions of claudin-2 that are

DMP-1 promoter-associated antisense strand non-coding RNA, panRNA-DMP-1, physically associates with EGFR to repress EGF-induced squamous cell carcinoma migration.

Shigeki Suzuki et al.

Molecular and cellular biochemistry, 476(4), 1673-1690 (2021-01-10)

Accumulating evidence suggests that specific non-coding RNAs exist in many types of malignant tissues, and are involved in cancer invasion and metastasis. However, little is known about the precise roles of non-coding RNAs in squamous cell carcinoma (SQCC) invasion and

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PD153035 hydrochloride

≥98% (HPLC)

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

InChI

SMILES string

InChI key

assay

form

storage condition

color

solubility

storage temp.

Quality Level

관련 카테고리

설명

Biochem/physiol Actions

Features and Benefits

안전성 정보

pictograms

signalword

hcodes

pcodes

Hazard Classifications

target_organs

저장 등급

wgk

flash_point_f

flash_point_c

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