SML0741

ML324

Name: ML324
Brand: SIGMA

≥98% (HPLC)

동의어(들):

N-(3-(Dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₁H₂₃N₃O₂

CAS 번호:

1222800-79-4

Molecular Weight:

349.43

NACRES:

NA.77

PubChem Substance ID:

329825592

UNSPSC Code:

12352200

MDL number:

MFCD28053518

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

주요 문서

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도움 문의

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도움 문의

InChI

1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26)

SMILES string

CN(C)CCCNC(C1=CC=C(C2=CC(O)=C(N=CC=C3)C3=C2)C=C1)=O

InChI key

QDBVSOZTVKXUES-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to light brown

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

ML324 is a potent JMJD2 demethylase inhibitor that is highly effective in reducing herpes simplex virus (HSV) IE gene expression. ML324 potently blocks the initiation of viral lytic infection and HSV-1 reactivation in the sensory ganglia of latently infected mice.

ML324 is a potent JMJD2 demethylase inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells.

David M Carter et al.

SLAS discovery : advancing life sciences R & D, 22(7), 801-812 (2017-03-28)

Human lysine demethylase (KDM) enzymes (KDM1-7) constitute an emerging class of therapeutic targets, with activities that support growth and development of metastatic disease. By interacting with and co-activating the androgen receptor, the KDM4 subfamily (KDM4A-E) promotes aggressive phenotypes of prostate

Histone Lysine Demethylases of JMJD2 or KDM4 Family are Important Epigenetic Regulators in Reward Circuitry in the Etiopathology of Depression.

Salil Saurav Pathak et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 42(4), 854-863 (2016-10-27)

Major depressive disorder (MDD) is debilitating mental illness and is one of the leading contributors to global burden of disease, but unfortunately newer and better drugs are not forthcoming. The reason is lack of complete understanding of molecular mechanisms underlying

Inhibition of CBP/β-catenin and porcupine attenuates Wnt signaling and induces apoptosis in head and neck carcinoma cells.

Robert Kleszcz et al.

Cellular oncology (Dordrecht), 42(4), 505-520 (2019-05-16)

Activation of the Wnt pathway contributes to the development of head and neck squamous cell carcinomas (HNSCC) and its inhibition has recently emerged as a promising therapeutic strategy. Here, we aimed at identifying suitable molecular targets for down-regulation of canonical

JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells.

Lei Duan et al.

Oncogene, 38(28), 5643-5657 (2019-04-11)

Platinum-based drugs such as cisplatin (CP) are the first-line chemotherapy for non-small-cell lung carcinoma (NSCLC). Unfortunately, NSCLC has a low response rate to CP and acquired resistance always occurs. Histone methylation regulates chromatin structure and is implicated in DNA repair.

KDM4A regulates HIF-1 levels through H3K9me3.

Grzegorz Dobrynin et al.

Scientific reports, 7(1), 11094-11094 (2017-09-13)

Regions of hypoxia (low oxygen) occur in most solid tumours and cells in these areas are the most aggressive and therapy resistant. In response to decreased oxygen, extensive changes in gene expression mediated by Hypoxia-Inducible Factors (HIFs) contribute significantly to

모든 관련된 서류 보기

문서

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

ML324

≥98% (HPLC)

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

InChI

SMILES string

InChI key

assay

form

storage condition

color

solubility

storage temp.

Quality Level

관련 카테고리

설명

Biochem/physiol Actions

Features and Benefits

안전성 정보

pictograms

signalword

hcodes

pcodes

Hazard Classifications

저장 등급

wgk

flash_point_f

flash_point_c

문서

시험 성적서(COA)

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