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Merck

SML0951

Salubrinal

≥98% (HPLC), powder, eIF2α dephosphorylation inhibitor

동의어(들):

(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl] 2-propenamide

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C21H17Cl3N4OS
CAS 번호:
405060-95-9
Molecular Weight:
479.81
UNSPSC Code:
12352200
NACRES:
NA.77

주요 문서

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제품 이름

Salubrinal, ≥98% (HPLC)

SMILES string

S=C(NC(NC(=O)\C=C\c3ccccc3)C(Cl)(Cl)Cl)Nc1c2ncccc2ccc1

InChI

1S/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+

InChI key

LCOIAYJMPKXARU-VAWYXSNFSA-N

assay

≥98% (HPLC)

form

powder

color

, White to brown to grey

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

Quality Level

100

관련 카테고리

Application

Salubrinal has been used to study the effect of stress-protective genes and pathways on organism development and lifespan. It has also been used to study the therapeutic potential of salubrinal in methamphetamine induced blood–brain barrier disruption.

Biochem/physiol Actions

Salubrinal is a selective Inhibitor of eIF2α (eukaryotic translation initiation factor 2 α-subunit) dephosphorylation, inhibiting global protein translation. Salubrinal is a specific inhibitor of ER Stress induced apoptosis.
Salubrinal is a selective Inhibitor of eIF2α dephosphorylation; specific inhibitor of ER Stress induced apoptosis.
Salubrinal maintains protein phosphorylation in order to offer protection against from the adverse effects of endoplasmic reticulum stress. Salubrinal prevents collagenase-mediated articular cartilage damage promoting downregulation of matrix metalloproteinase 13.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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시험 성적서(COA)

Lot/Batch Number
0000300823
0000300823
0000473438
0000473438
0000447305

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문서 라이브러리 방문

Protection of Bcl-2 by salubrinal.
Kessel D.
Biochemical and Biophysical Research Communications, 346(4), 1320-1323 (2006)
K Hamamura et al.
Osteoarthritis and cartilage, 21(5), 764-772 (2013-03-12)
Stress to the endoplasmic reticulum (ER) and inflammatory cytokines induce expression and activity of matrix metalloproteinase 13 (MMP13). Since a synthetic agent, salubrinal, is known to alleviate ER stress and attenuate nuclear factor kappa B (NFκB) signaling, we addressed a
Muhammad M Hossain et al.
Toxicological sciences : an official journal of the Society of Toxicology, 167(1), 249-257 (2018-09-25)
Endoplasmic reticulum (ER) stress is a significant contributor to neurodegeneration and cognitive dysfunction. Recently, we reported that repeated exposure to the pyrethroid insecticide deltamethrin caused ER stress in the hippocampus of adult mice, which was accompanied by deficits in learning
Rescue of a developmental arrest caused by a C. elegans heat-shock transcription-factor mutation by loss of ribosomal S6-kinase activity.
Chisnell P J D, et al.
bioRxiv, 310086-310086 (2018)
Wenhui Tao et al.
American journal of translational research, 14(5), 3360-3371 (2022-06-16)
Apoptosis induced by excessive endoplasmic reticulum (ER) stress is accompanied by the occurrence and progression of myocardial ischemia/reperfusion (I/R) injury. COX-2 is also known to affect the development of I/R damage in myocardium. However, the interaction between COX-2 and ER
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Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

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