SML1414
Liproxstatin-1
>98% (HPLC), powder, ferroptosis inhibitor
동의어(들):
N-[(3-Chlorophenyl)methyl]-spiro[piperidine-4,2′(1′H)-quinoxalin]-3′-amine, N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4′-piperidine]-2-amine
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C19H21ClN4
CAS 번호:
Molecular Weight:
340.85
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
Liproxstatin-1, >98% (HPLC)
SMILES string
ClC1=CC(CNC2=NC3=CC=CC=C3NC24CCNCC4)=CC=C1
InChI
1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)
InChI key
YAFQFNOUYXZVPZ-UHFFFAOYSA-N
assay
>98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
Quality Level
Application
Liproxstatin-1 has been used as a cell death inhibitor in the cell viability assay and for the determination of lipid peroxidation.
Biochem/physiol Actions
Liproxstatin-1 is a potent inhibitor of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species (ROS). Liproxstatin-1 suppressed ferroptosis in human cells and in an ischaemia/reperfusion-induced tissue injury model in mice. Knockout of glutathione peroxidase 4 (Gpx4) Has been shown to cause cell death by ferroptosis. Liproxstatin-1 was able to suppress ferroptosis in Gpx4 knock-out mice.
Liproxstatin-1 is a potent inhibitor of ferroptosis.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis.
Ingold I, et al.
Cell, 172(3), 409-422 (2018)
Alejandra M Martinez et al.
FEBS open bio, 9(4), 582-593 (2019-04-16)
Ferroptosis is a form of regulated cell death that is driven by lethal accumulation of lipid peroxides upon inhibition of glutathione peroxidase 4 (GPx4). Deletion of the Gpx4 gene in mice revealed that neurons are sensitive to ferroptosis in vivo. However
Yilong Zou et al.
Nature, 585(7826), 603-608 (2020-09-18)
Ferroptosis-an iron-dependent, non-apoptotic cell death process-is involved in various degenerative diseases and represents a targetable susceptibility in certain cancers1. The ferroptosis-susceptible cell state can either pre-exist in cells that arise from certain lineages or be acquired during cell-state transitions2-5. However
Wen-Hsuan Yang et al.
Molecular cancer research : MCR, 18(1), 79-90 (2019-10-24)
Ovarian cancer is the deadliest gynecologic cancer. Despite recent advances, clinical outcomes remain poor, necessitating novel therapeutic approaches. To investigate metabolic susceptibility, we performed nutrigenetic screens on a panel of clear cell and serous ovarian cancer cells and identified cystine
Anushka Katikaneni et al.
Nature cell biology, 22(9), 1049-1055 (2020-09-02)
Rapid wound detection by distant leukocytes is essential for antimicrobial defence and post-infection survival1. The reactive oxygen species hydrogen peroxide and the polyunsaturated fatty acid arachidonic acid are among the earliest known mediators of this process2-4. It is unknown whether
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