SRP3015
Beta NGF human
recombinant, expressed in E. coli, โฅ98% (SDS-PAGE), suitable for cell culture
๋์์ด(๋ค):
beta-Nerve Growth Factor
์กฐ์ง ๋ฐ ๊ณ์ฝ ๊ฐ๊ฒฉ์ ๋ณด๋ ค๋ฉด ๋ก๊ทธ์ธ๋ฅผ ํด๋ฆญํฉ๋๋ค.
ํฌ๊ธฐ ์ ํ
์ ํ์ ๋ณด (DICE ๋ฐฐ์ก ์ ๋น์ฉ ๋ณ๋)
NACRES:
NA.32
UNSPSC Code:
12352202
๊ธฐ์ ์๋น์ค
๋์์ด ํ์ํ์ ๊ฐ์? ์ ํฌ ์๋ จ๋ ๊ณผํ์ ํ์ด ๋์๋๋ฆฌ๊ฒ ์ต๋๋ค.
๋์ ๋ฌธ์๊ธฐ์ ์๋น์ค
๋์์ด ํ์ํ์ ๊ฐ์? ์ ํฌ ์๋ จ๋ ๊ณผํ์ ํ์ด ๋์๋๋ฆฌ๊ฒ ์ต๋๋ค.
๋์ ๋ฌธ์biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE)
form
lyophilized
potency
<1.0 ng/mL ED50
mol wt
(Noncovalent Homodimer, 13.6 kDa (121 amino acids))
packaging
pkg of 20 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20ยฐC
Gene Information
human ... NGF(4803)
์ ์ฌํ ์ ํ์ ์ฐพ์ผ์ญ๋๊น? ๋ฐฉ๋ฌธ ์ ํ ๋น๊ต ์๋ด
General description
ฮฒ-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. ฮฒ-NGF is a potent neurotrophic factor that signals through its receptor ฮฒ-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. ฮฒ-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human ฮฒ-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity.
Application
ฮฒ NGF human has been used in immunohistochemistry.
Biochem/physiol Actions
ฮฒ-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. The functional form of human b-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity.
Physical form
Lyophilized from a 0.2 ฮผm filtered solution containing0.1% Trifluoroacetic Acid (TFA)
Preparation Note
Sterile water at 0.1 mg/mLCentrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80ยฐC, and avoid repeat freeze thaws.
Other Notes
SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA
์ ์ฅ ๋ฑ๊ธ
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
๊ฐ์ฅ ์ต์ ๋ฒ์ ์ค ํ๋๋ฅผ ์ ํํ์ธ์:
์ด ์ ํ์ ์ด๋ฏธ ๊ฐ์ง๊ณ ๊ณ์ญ๋๊น?
๋ฌธ์ ๋ผ์ด๋ธ๋ฌ๋ฆฌ์์ ์ต๊ทผ์ ๊ตฌ๋งคํ ์ ํ์ ๋ํ ๋ฌธ์๋ฅผ ์ฐพ์๋ณด์ธ์.
H Zhang et al.
European journal of histochemistry : EJH, 59(3), 2522-2522 (2015-10-03)
The nerve growth factor (NGF) not only has an essential effect on the nervous system, but also plays an important role in a variety of non-neuronal systems, such as the reproductive system. The aim of this study was to investigate
The nerve growth factor 35 years later.
R Levi-Montalcini
Science (New York, N.Y.), 237(4819), 1154-1162 (1987-09-04)
Huiyu Chen et al.
Journal of inflammation (London, England), 16, 27-27 (2020-01-01)
In herpes simplex epithelial keratitis, excessive TLR3-induced cellular responses after virus infection evoke inflammatory cascades that might be destructive to the host cornea. Nerve growth factor (NGF), a pluripotent neurotrophic factor with immune regulatory effect, was proved to be effective
A Ullrich et al.
Nature, 303(5920), 821-825 (1983-06-30)
Nerve growth factor (NGF) is thought to have a profound effect on the development and maintenance of sympathetic and embryonic sensory neurones (see refs 1-3 for review). NGF activity isolated from the male mouse submaxillary gland (MSG) consists of three
Li Xiao et al.
Neural regeneration research, 15(12), 2270-2272 (2020-07-01)
As an aging-associated degenerative disease, Alzheimer's disease is characterized by the deposition of amyloid beta (Aฮฒ), oxidative stress, inflammation, dysfunction and loss of cholinergic neurons. Colla Corii Asini (CCA) is a traditional Chinese medicine which has been used for feebleness-related
์์ฌ์ ๊ณผํ์ํ์ ์๋ช ๊ณผํ, ์ฌ๋ฃ ๊ณผํ, ํํ ํฉ์ฑ, ํฌ๋ก๋งํ ๊ทธ๋ํผ, ๋ถ์ ๋ฐ ๊ธฐํ ๋ง์ ์์ญ์ ํฌํจํ ๋ชจ๋ ๊ณผํ ๋ถ์ผ์ ๊ฒฝํ์ด ์์ต๋๋ค..
๊ณ ๊ฐ์ง์ํ์ผ๋ก ์ฐ๋ฝ๋ฐ๋๋๋ค.