T0535

Tolfenamic acid

Name: Tolfenamic acid
Brand: SIGMA

NSAID

동의어(들):

2 (3-Chloro-2-methylanilino)benzoic acid, 2-([3-Chloro-2-methylphenyl]amino)benzoic acid

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₄H₁₂ClNO₂

CAS 번호:

13710-19-5

Molecular Weight:

261.70

NACRES:

NA.77

PubChem Substance ID:

24899896

UNSPSC Code:

12352202

EC Number:

237-264-3

MDL number:

MFCD00133865

주요 문서

모든 문서 보기

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InChI key

YEZNLOUZAIOMLT-UHFFFAOYSA-N

InChI

1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)

SMILES string

Cc1c(Cl)cccc1Nc2ccccc2C(O)=O

assay

≥98% (TLC)

form

powder

solubility

ethanol: 50 mg/mL, clear, greenish-yellow

Quality Level

200

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General description

Tolfenamic acid is a fenamate and is made up of a monocarboxylate diphenylamine nucleus.

Application

Tolfenamic acid has been used in Arabidopsis bud assay for activity comparison with quinazolinedione derivatives (QADD) based compounds.

Biochem/physiol Actions

Non-steroidal anti-inflammatory agent. Interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor.

Tolfenamic acid is involved in the inhibition of prostaglandin synthesis. It also plays a role in apoptosis of head and neck cancer cells.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Lot/Batch Number

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문서 라이브러리 방문

Polymer-induced heteronucleation of tolfenamic acid: structural investigation of a pentamorph.

Vilmalí López-Mejías et al.

Journal of the American Chemical Society, 131(13), 4554-4555 (2009-04-02)

The nonsteroidal anti-inflammatory drug (NSAID) tolfenamic acid (TA), previously thought to be dimorphic, is demonstrated to have at least five polymorphs. The new forms were uncovered through the emerging screening technique of polymer-induced heteronucleation (PIHn). The presence of conformational changes

Polymer-induced heteronucleation of tolfenamic acid: structural investigation of a pentamorph

Lopez M V, et al.

Journal of the American Chemical Society, 131(13), 4554-4555 (2009)

Chemical synthesis and characterization of a new quinazolinedione competitive antagonist for strigolactone receptors with an unexpected binding mode

Hamiaux C, et al.

The Biochemical Journal, 476(12), 1843-1856 (2019)

Tolfenamic acid, metoclopramide, caffeine and their combinations in the treatment of migraine attacks.

R A Tokola et al.

Cephalalgia : an international journal of headache, 4(4), 253-263 (1984-12-01)

Tolfenamic acid is a fenamate which inhibits prostaglandin (PG) biosynthesis and may act as a PG antagonist as well. Caffeine and metoclopramide are used in combination with analgesics and ergotamine in the treatment of migraine attacks, but controlled clinical studies

Small molecule tolfenamic acid inhibits PC-3 cell proliferation and invasion in vitro, and tumor growth in orthotopic mouse model for prostate cancer.

Umesh T Sankpal et al.

The Prostate, 72(15), 1648-1658 (2012-04-05)

Specificity protein (Sp) transcription factors are implicated in critical cellular and molecular processes associated with cancer that impact tumor growth and metastasis. The non-steroidal anti-inflammatory drug, tolfenamic acid (TA) is known to inhibit Sp proteins in some human cancer cells

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Tolfenamic acid

NSAID

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

InChI key

InChI

SMILES string

assay

form

solubility

Quality Level

설명

General description

Application

Biochem/physiol Actions

안전성 정보

pictograms

signalword

hcodes

pcodes

Hazard Classifications

저장 등급

wgk

flash_point_f

flash_point_c

ppe

문서

시험 성적서(COA)

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