T2265
Tetraethylammonium chloride
synthetic (organic), ≥98% (titration), K+ channels blocker, powder
동의어(들):
TEA chloride
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
(C2H5)4N(Cl)
CAS 번호:
Molecular Weight:
165.70
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352107
EC Number:
200-267-5
MDL number:
Beilstein/REAXYS Number:
3563247
Form:
powder
Assay:
≥98% (titration)
Biological source:
synthetic (organic)
제품 이름
Tetraethylammonium chloride, ≥98% (titration)
InChI key
YMBCJWGVCUEGHA-UHFFFAOYSA-M
InChI
1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1
SMILES string
[Cl-].CC[N+](CC)(CC)CC
biological source
synthetic (organic)
assay
≥98% (titration)
form
powder
technique(s)
blocking: suitable
color
white to light yellow
Quality Level
Gene Information
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관련 카테고리
Application
Tetraethylammonium chloride (TEAC) has been used:
- used for inhibition of peroxynitrite induced relaxation in rat aorta rings
- as a pharmacological blocker of K+ current and Ca2+ induced K+ current in antennal lobe neurons
- for the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties
Biochem/physiol Actions
Blocks K+ channels; blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents.
Tetraethylammonium chloride (TEAC) blocks K+ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite. It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients. TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals. TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax).
Disclaimer
moisture sensitive, handle under argon
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
201.2 °F - closed cup
flash_point_c
94 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
Tetraethylammonium enhances the rectal and colonic motility in rats and human in vitro
Li Z, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 384(2), 147-155 (2011)
Dissociation enzyme effects on the potassium currents of inner hair cells isolated from guinea-pig cochlea
Kimitsuki T, et al.
Hearing Research, 199(1-2), 135-139 (2005)
Early potassium channel blockade improves sepsis-induced organ damage and cardiovascular dysfunction
Sordi R, et al.
British Journal of Pharmacology, 163(6), 1289-1301 (2011)
Tetraethylammonium inhibits glioma cells via increasing production of intracellular reactive oxygen species
Yang KB, et al.
Chemotherapy, 55(5), 372-380 (2009)
Differences of Ca2+ handling properties in identified central olfactory neurons of the antennal lobe
Pippow A, et al.
Cell Calcium, 46(2), 87-98 (2009)
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