T2928
Anti-Tyrosine Hydroxylase Antibody
mouse monoclonal, TH-16
동의어(들):
Anti-DYT14, Anti-DYT5b, Anti-TYH
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
TH-16, monoclonal
Application:
immunohistochemistry
immunoprecipitation (IP)
microarray
western blot
immunoprecipitation (IP)
microarray
western blot
Species reactivity:
rat, sheep, human, monkey, bovine, rabbit, guinea pig
Citations:
209
Technique(s):
immunohistochemistry: suitable
immunoprecipitation (IP): suitable using native or SDS-denatured TH.
microarray: suitable
western blot: 1:8,000 using extracts of cultured rat adrenal pheochromocytoma (PC12) cells.
immunoprecipitation (IP): suitable using native or SDS-denatured TH.
microarray: suitable
western blot: 1:8,000 using extracts of cultured rat adrenal pheochromocytoma (PC12) cells.
Uniprot accession no.:
제품 이름
Monoclonal Anti-Tyrosine Hydroxylase antibody produced in mouse, clone TH-16, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
TH-16, monoclonal
contains
15 mM sodium azide
species reactivity
rat, sheep, human, monkey, bovine, rabbit, guinea pig
technique(s)
immunohistochemistry: suitable
immunoprecipitation (IP): suitable using native or SDS-denatured TH.
microarray: suitable
western blot: 1:8,000 using extracts of cultured rat adrenal pheochromocytoma (PC12) cells.
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Biochem/physiol Actions
Tyrosine hydroxylase (TH) catalyzes the first rate limiting step in the biosynthesis of catecholamine neurotransmitter i.e. the conversion of L-tyrosine to L-dopa. Inhibition of TH by L-phenylalanine, might play a crucial role in phenylketonuria and block the synthesis of norepinephrine. Activity of TH can be regulated by phosphorylation. Decreased expression of TH is associated with various neuropsychiatric diseases such as schizophrenia and Parkinson′s disease (PD).
The antibody recognizes an epitope present in the N-terminal region (between aa 40-152) of both rodent and human tryosine hydroxylase. TH-16 detects both the intact subunits and the 59/57 kDa doublet and an array of decreasing molecular weight TH forms resulting from severe proteolysis.
Application
Monoclonal Anti-Tyrosine Hydroxylase antibody produced in mouse has also been used in
- western blotting
- immunofluorescence labelling
- immunohistochemical staining
- enzyme linked immunosorbent assay (ELISA)
- dot blot
- immunoprecipitation
- immunocytochemistry
Monoclonal Anti-tyrosine hydroxylase antibody produced in mouse has been used in immunohistochemistry and double immunofluorescence labeling.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-Tyrosine Hydroxylase (mouse IgG1 isotype) is derived from the TH-16 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice. Tyrosine hydroxylase (TH) exists in four isoforms in humans. They are are TH-1 (M.W. 55,600), TH-2 (4 additional amino acids; M.W. 56,000), TH-3, (27 additional amino acids; M.W. 58,100), and TH-4 (4 plus 27 additional amino acids; 58,500). Only humans express all four isoforms; all other anthropoids express only the TH-1 and TH-2 isoforms.
Tyrosine hydroxylase (TH) is encoded by the gene mapped to human chromosome 11p15. TH is a tetramer of four identical subunits, which is characterized with a regulatory, catalytic and tetramerization domains. The enzyme utilizes tyrosine, tetrahydrobiopterin (BH4) and O2 as cosubstrates, and Fe2+ as a cofactor.
Immunogen
rat tyrosine hydroxylase (TH).
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저장 등급
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Selective cholinergic depletion of pedunculopontine tegmental nucleus aggravates freezing of gait in parkinsonian rats
Xiao H, et al.
Neuroscience Letters, 659, 92-98 (2017)
Influence of aging on the dopaminergic neurons in the substantia nigra pars compacta of rats
Gao J, et al.
Current Aging Science, 4(1), 19-24 (2011)
The astrocytic response to the dopaminergic denervation of the striatum.
Morales I, et al.
Journal of Neurochemistry, 139(1), 81-95 (2016)
Álvaro García-Avilés et al.
Frontiers in neuroanatomy, 9, 33-33 (2015-04-09)
Methylphenidate (MPD) is a commonly administered drug to treat children suffering from attention deficit hyperactivity disorder (ADHD). Alterations in septal driven hippocampal theta rhythm may underlie attention deficits observed in these patients. Amongst others, the septo-hippocampal connections have long been
Shumin Ma et al.
Oxidative medicine and cellular longevity, 2016, 4693703-4693703 (2016-05-20)
Excessive reactive oxygen species/reactive nitrogen species (ROS/RNS) produced as a result of ageing causes damage to macromolecules and organelles or leads to interference of cell signalling pathways, which in turn results in oxidative stress. Oxidative stress occurs in many neurodegenerative
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