T4009

Taurocholic acid sodium salt hydrate

Name: Taurocholic acid sodium salt hydrate
Brand: SIGMA

≥95% (HPLC)

동의어(들):

2-[(3α,7α,12α-Trihydroxy-24-oxo-5β-cholan-24-yl)amino]ethanesulfonic acid, 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide, Sodium taurocholate hydrate

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₆H₄₄NNaO₇S · xH₂O

CAS 번호:

345909-26-4

Molecular Weight:

537.68 (anhydrous basis)

NACRES:

NA.25

PubChem Substance ID:

24900186

UNSPSC Code:

12161900

EC Number:

205-653-7

MDL number:

MFCD00150819

주요 문서

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InChI key

RDAJAQDLEFHVNR-NEMAEHQESA-M

InChI

1S/C26H45NO7S.Na.H2O/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29;;/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34);;1H2/q;+1;/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-;;/m1../s1

SMILES string

[Na+].[H]O[H].[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@H](CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(=O)NCCS([O-])(=O)=O

biological source

synthetic (organic)

description

anionic

assay

≥95% (HPLC)

form

powder

mol wt

micellar avg mol wt 2100

aggregation number

CMC

3-11 mM (20-25°C)

functional group

sulfonic acid

shipped in

ambient

storage temp.

room temp

Quality Level

200

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General description

Taurocholic acid sodium salt hydrate is a bile acid with detergent capabilities.

Application

Anionic detergent used for protein solubilization.

Taurocholic acid sodium salt hydrate has been used in a study to assess the adsorption of bile acids and salts to vegetable fibrous tissue. It has also been used in a study to investigate a method for determination of conjugated and unconjugated bile salts in serum and jejunal fluid.

Biochem/physiol Actions

Non-sulfated bile salt, physiological transport substrate for the bile salt export pump/sister of Pgp (BSEP/spgp), Na⁽⁺⁾/taurocholate cotransporter (NTCP) and MRP3 into the hepatic carnalicular.

Non-sulfated bile salt.

Preparation Note

Synthesized from cholic acid

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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문서 라이브러리 방문

Studies on the Antibacterial Properties of the Bile Acids and some Compounds Derived from Cholanic Acid

M. Stacey and M. Webb

Proc. Royal Soc. Lond. B., 134, 523-523 (1947)

Clostridium difficile extracytoplasmic function σ factor σV regulates lysozyme resistance and is necessary for pathogenesis in the hamster model of infection.

Theresa D Ho et al.

Infection and immunity, 82(6), 2345-2355 (2014-03-26)

Clostridium difficile is a clinically important pathogen and the most common cause of hospital-acquired infectious diarrhea. Expression of the C. difficile gene csfV, which encodes σ(V), an extracytoplasmic function σ factor, is induced by lysozyme, which damages the peptidoglycan of

Studies on the adsorption of bile salts to non-absorbed components of diet.

M A Eastwood et al.

Biochimica et biophysica acta, 152(1), 165-173 (1968-01-10)

Lactobacilli with probiotic potential in the prairie vole (Microtus ochrogaster).

Senait Assefa et al.

Gut pathogens, 7, 35-35 (2016-01-01)

Recent research suggests integration of the intestinal microbiota in gut-brain communication which could lead to new approaches to treat neurological disorders. The highly social prairie voles are an excellent model system to study the effects of environmental factors on social

Analysis of conjugated and unconjugated bile acids in serum and jejunal fluid of normal subjects.

A Tangerman et al.

Clinica chimica acta; international journal of clinical chemistry, 159(2), 123-132 (1986-09-15)

A reliable method is described for the determination of conjugated and unconjugated bile acids in serum and jejunal fluid. Bile acids are extracted using reverse-phase octadecylsilane bonded silica cartridges and are separated into their unconjugated and conjugated fractions using the

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Probiotics and Human Health

Probiotics exhibit an inhibitory effect on pathogens, help prevent chronic intestinal inflammatory diseases or atopic syndromes, and support the immune system.

프로토콜

HPLC Separation of Bile Acids with Ascentis Express C18

Investigate bile acid roles in gut hormone profiles and glycemic control, vital for clinical labs exploring potential mechanisms.

Taurocholic acid sodium salt hydrate

≥95% (HPLC)

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

InChI key

InChI

SMILES string

biological source

description

assay

form

mol wt

aggregation number

CMC

functional group

shipped in

storage temp.

Quality Level

관련 카테고리

설명

General description

Application

Biochem/physiol Actions

Preparation Note

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

ppe

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