T5076
Anti-β-Tubulin III Antibody
mouse monoclonal, SDL.3D10
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
SDL.3D10, monoclonal
Application:
ARR, DB, ELISA (i), ICC, IHC, WB
Citations:
82
제품 이름
Anti-β-Tubulin Isotype III antibody, Mouse monoclonal, clone SDL.3D10, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
SDL.3D10, monoclonal
form
buffered aqueous solution
species reactivity
mouse, rat, human, boar, bovine
packaging
antibody small pack of 25 μL
concentration
~2 mg/mL
technique(s)
dot blot: suitable, immunocytochemistry: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, microarray: suitable, western blot: 0.1-0.2 μg/mL using rat brain extract
isotype
IgG2b
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TUBB3(10381)
mouse ... Tubb3(22152)
rat ... Tubb3(246118)
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General description
Tubulin β 3 class III (TUBB3) encodes for the microtubule protein tubulin β‐3, which is majorly expressed in neurons. The gene is located on human chromosome 16q24.3.
Tubulin is the main constituent of microtubules made up of two similar polypeptides α and β, each with 50 kD (approx.) molecular weight. It has several cellular functions like mitosis, meiosis, some forms of organellar movement, intracellular transport, flagellar movement and cytoskeletal functions. Monoclonal anti-β-tubulin isotype III antibody can be used in microarray and western blotting. It can also be used in immunoblotting. Mouse anti-β-tubulin isotype III antibody reacts specifically with an epitope present on the β-tubulin (isotype III) of bovine, rat, mouse, boar and human but not with tubulin present in chicken brain preparation or in a chicken fibroblasts cell line.
Immunogen
peptide corresponding to the carboxy-terminal sequence of human β-tubulin isotype III, conjugated to BSA.
Application
Monoclonal Anti-β-Tubulin Isotype III antibody produced in mouse has been used in immunolabelling and flow cytometry.
Monoclonal anti-β-tubulin isotype III antibody (diluted 1:500) can be used as a primary antibody in immunocytochemical analysis of neurons. It can also be used for the localization of isotype III of β-tubulin by several immunochemical assays like dot blot, ELISA and immunohistochemistry.
Biochem/physiol Actions
Tubulin β 3 class III (TUBB3) regulates neurogenesis and is involved in axon guidance and maintenance. Mutations in this gene is associated with hypoplasia of commissural axon (CA), congenital fibrosis of the extraocular muscles type 3 (CFEOM3) and dysgyria.
Physical form
Solution in 0.01 M phosphate buffered saline containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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저장 등급
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Childhood-onset schizophrenia case with 2.2 Mb deletion at chromosome 3p12. 2-p12. 1 and two large chromosomal abnormalities at 16q22. 3-q24. 3 and Xq23-q28
Rudd D, et al.
Clinical case reports, 3(4), 201-207 (2015)
Two unique TUBB3 mutations cause both CFEOM3 and malformations of cortical development
Whitman MC, et al.
American Journal of Medical Genetics. Part A, 170(2), 297-305 (2016)
Evaluation of tubulin beta-3 as a novel senescence-associated gene in melanocytic malignant transformation
Orfanidis K, et al.
Pigment Cell & Melanoma Research, 30(2), 243-254 (2017)
J Pĕknicová et al.
Biology of reproduction, 65(3), 672-679 (2001-08-22)
The exposure of tubulin epitopes was studied in ejaculated boar spermatozoa using a panel of four monoclonal antibodies specific to the N-terminal or C-terminal structural domains of tubulin and three monoclonal antibodies against class III beta-tubulin. The specificity of the
Cytoskeleton in action: lissencephaly, a neuronal migration disorder
Moon HM and Wynshaw-Boris A
Wiley interdisciplinary reviews. Developmental biology, 2(2), 229-245 (2013)
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