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Merck

T9034

Taurocholic acid sodium salt hydrate

BioXtra, ≥95% (HPLC)

동의어(들):

2-[(3α,7α,12α-Trihydroxy-24-oxo-5β-cholan-24-yl)amino]ethanesulfonic acid, 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide, Sodium taurocholate hydrate

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크기 선택


제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C26H44NNaO7S · xH2O
CAS 번호:
Molecular Weight:
537.68 (anhydrous basis)
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12161900
EC Number:
205-653-7
MDL number:
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InChI

1S/C26H45NO7S.Na.H2O/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29;;/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34);;1H2/q;+1;/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-;;/m1../s1

InChI key

RDAJAQDLEFHVNR-NEMAEHQESA-M

SMILES string

[Na+].[H]O[H].[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@H](CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(=O)NCCS([O-])(=O)=O

biological source

synthetic (organic)

description

anionic

product line

BioXtra

assay

≥95% (HPLC)

form

powder

mol wt

micellar avg mol wt 2100

aggregation number

4

impurities

≤0.005% Phosphorus (P), ≤0.1% Insoluble matter

CMC

3-11 mM (20-25°C)

solubility

H2O: 0.2 M, clear, colorless to faintly yellow

anion traces

chloride (Cl-): ≤0.05%, sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%, Ca: ≤0.005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.01%, Mg: ≤0.005%, NH4+: ≤0.1%, Pb: ≤0.001%, Zn: ≤0.0005%

application(s)

detection

functional group

sulfonic acid

shipped in

ambient

storage temp.

room temp

Quality Level

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Application

Anionic detergent used for protein solubilization.
Taurocholic acid, a bile acid, may be used in studies of the physiological effects of bile salts on intestinal function and bacterial flora development.

Biochem/physiol Actions

Non-sulfated bile salt, physiological transport substrate for the bile salt export pump/sister of Pgp (BSEP/spgp), Na(+)/taurocholate cotransporter (NTCP) and MRP3 into the hepatic carnalicular.
Non-sulfated bile salt.

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Xin Chen et al.
American journal of physiology. Gastrointestinal and liver physiology, 303(2), G199-G208 (2012-05-12)
Reflux of acid and bile acids contributes to epithelial tissue injury in gastro-esophageal reflux disease. However, the influence of refluxed material on human esophageal stratified epithelial barrier function and tight junction (TJ) proteins has not been fully elucidated. Here, we
Y Sai et al.
Journal of cell science, 112 ( Pt 24), 4535-4545 (1999-11-27)
The bile canalicular membrane contains several ATP-dependent transporters that are involved in biliary secretion. Canalicular transporters are synthesized in ER, modified in Golgi and transported to the apical plasma membrane. However, the route and regulation of intracellular trafficking of ATP-dependent
M-K Choi et al.
Xenobiotica; the fate of foreign compounds in biological systems, 39(2), 171-181 (2009-03-04)
1. The purpose of this study was to investigate the involvement of rat Mrp2 and human MRP2 in benzylpenicillin transport using canalicular liver plasma membrane (cLPM) vesicles isolated from Sprague-Dawley or Easai hyperbilirubinemic (EHBR) rats, and MDCKII cells overexpressing MRP2.
Mehmet Ali Kosekli et al.
Revista da Associacao Medica Brasileira (1992), 65(2), 204-210 (2019-03-21)
The effects of Certolizumab, a pegylated monoclonal antibody to tumor necrosis factor α, on experimentally induced acute pancreatitis (AP) were examined. Thirty-six Wistar Albino male rats were randomly divided into four groups. Group I was the control group and no
Michael D Aleo et al.
Journal of applied toxicology : JAT, 39(8), 1192-1207 (2019-05-28)
Marketed (bosentan, ambrisentan) and discontinued (sitaxsentan, CI-1034) endothelin receptor antagonists were examined in the human micropatterned hepatocyte co-culture (MPCC) model HepatoPac® . Differences across hepatocellular health (cellular adenosine triphosphate/glutathione content), function (urea production/albumin secretion) and taurocholic acid transport (biliary clearance/excretion

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