T9265
Thyrotropic hormone from human pituitary
lyophilized powder, ≥6.2 IU/mg (immunoassay, non-sterile)
동의어(들):
hTSH, TSH, Thyroid stimulating hormone
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
biological source
human pituitary glands
Quality Level
sterility
non-sterile
form
lyophilized powder
specific activity
≥6.2 IU/mg (immunoassay, non-sterile)
storage condition
(Keep container tightly closed in a dry and well-ventilated place)
technique(s)
cell culture | mammalian: suitable
impurities
HIV Antibodies
Antibody to HCV
Antibody to HBV or Presence of HBSAG, tested negative
shipped in
ambient
storage temp.
2-8°C
Gene Information
human ... TSHB(7252), TSHR(7253)
General description
Research area: Cell Signaling
Thyrotropic hormone or thyroid stimulating hormone (TSH) belongs to the glycoprotein hormone family. Thyrotroph cells of the anterior pituitary gland produces TSH and is stored in the secretory granules. It comprises a heterodimer of two noncovalently linked subunits, α and β.
Thyrotropic hormone or thyroid stimulating hormone (TSH) belongs to the glycoprotein hormone family. Thyrotroph cells of the anterior pituitary gland produces TSH and is stored in the secretory granules. It comprises a heterodimer of two noncovalently linked subunits, α and β.
Application
Thyrotropic hormone from human pituitary has been used as a supplement in the fetal thyroid organoid culture medium for stimulating maturation. It has also been used as a medium supplement for primary cell culture, and is used further to study the molecular mechanisms of estrogen-mediated growth stimulation of human thyroid tumor cells.
Biochem/physiol Actions
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.
The product can enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer celllines.TSHR activated by TSH activates both the adenosine 3′,5′-cyclic monophosphate (cAMP) pathway (via Gsa) and the phosphoinositol/calcium (IP/Ca2+; via Gq) second messenger signaling pathway by interacting with Gs and Gq G-proteins. In mature adipocytes, TSH aids in lipid metabolism by inhibiting fatty acid synthase (FASN) expression via, activating protein kinase A (PKA)-dependent phosphorylation of extracellular signal-regulated kinases/p42/p44 (ERK1/2), and c-Jun N-terminal kinase (JNK).
In children, thyroid hormones are very much essential for the normal cognition and neurodevelopment. Thyroid-stimulating hormone (TSH) test is mainly used to diagnose thyroid function.
Packaging
Package size based on hormone
Physical form
Contains hormone and salts from approx. 0.1 mL of 0.05 M phosphate buffer, pH 7.4.
저장 등급
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Thyroid-stimulating hormone
The pituitary, 163-201 (2017)
D Manole et al.
The Journal of clinical endocrinology and metabolism, 86(3), 1072-1077 (2001-03-10)
Thyroid tumors are about 3 times more frequent in females than in males. Epidemiological studies suggest that the use of estrogens may contribute to the pathogenesis of thyroid tumors. In a very recent study a direct growth stimulatory effect of
Physiology, Thyroid Stimulating Hormone
Pirahanchi Y, et al.
StatPearls [Internet] (2022)