V8639
VO-OHpic trihydrate
≥98% (HPLC), solid
동의어(들):
(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C12H9N2O8V · H · 3H2O
CAS 번호:
Molecular Weight:
415.20
UNSPSC Code:
41121801
PubChem Substance ID:
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
solid
color
gray
solubility
DMSO: >10 mg/mL
storage temp.
−20°C
SMILES string
O.O.O.O.Oc1cccnc1C(=O)O[VH]2(=O)OC(=O)c3cccnc3O2
InChI
1S/2C6H5NO3.4H2O.O.V.H/c2*8-4-2-1-3-7-5(4)6(9)10;;;;;;;/h2*1-3,8H,(H,9,10);4*1H2;;;/q;;;;;;;+3;/p-3
InChI key
QVBVJWFAUFEGMT-UHFFFAOYSA-K
General description
VO-OHpic is a vanadium complex. VO-OHpic might act as a possible pro-senescence anti-cancer drug for treating cancers with reduced phosphatase and tensin homolog (PTEN) expression. It blocks cell viability, cell proliferation, colony formation and induced senescence-associated β-galactosidase activity in Hep3B cells.
Application
VO-OHpic trihydrate has been used in studying the role of phosphatase and tensin homolog (PTEN) in polycomb repressive complex 2 (PRC2)-mediated apoptosis. It also has been used as a PTEN inhibitor to study the neuroprotective effect of melatonin in amyloid beta (Aβ)-induced neurotoxicity via PTEN pathway.
Biochem/physiol Actions
VO-OHpic trihydrate is a PTEN (phosphatase and tensin homologue deleted on chromosome 10) inhibitor.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells
Benoit YD, et al.
Experimental Cell Research, 319(10), 1463-1470 (2013)
Melatonin protects against Abeta-induced neurotoxicity in primary neurons via miR-132/PTEN/AKT/FOXO3a pathway
Zhao Y, et al.
Biofactors (2018)
Characterisation of the PTEN inhibitor VO-OHpic
Mak LH, et al.
Journal of Chemical Biology, 3(4), 157-163 (2010)
Ying-Zi Liu et al.
International journal of oncology, 45(1), 104-112 (2014-04-24)
Colon cancer is one of the most common malignancies and the treatments for colon cancer have been developed substantially in the last decades, but there is still a great clinical need to explore new treatment regimens due to the undesirable
A PTEN inhibitor displays preclinical activity against hepatocarcinoma cells
Augello G, et al.
Cell Cycle, 15(4), 573-583 (2016)
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