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Merck

V9879

[Arg8]-Vasopressin acetate salt

synthetic (organic), ≥95% (HPLC), vasopressin receptor agonist, powder

동의어(들):

β-Hypophamine, AVP, Antidiuretic hormone, Arginine vasopressin

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C46H65N15O12S2 · xC2H4O2
CAS 번호:
113-79-1
Molecular Weight:
1084.23 (free base basis)
NACRES:
NA.32
PubChem Substance ID:
24900773
UNSPSC Code:
51111800
EC Number:
204-035-4
MDL number:
MFCD00133939
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥95% (HPLC)

주요 문서

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제품 이름

[Arg8]-Vasopressin acetate salt, ≥95% (HPLC)

InChI key

ZHFGXNMADRRGQP-HPILINOVSA-N

InChI

1S/C46H65N15O12S2.C2H4O2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25;1-2(3)4/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53);1H3,(H,3,4)/t27-,28-,29-,30-,31-,32-,33-,34-;/m0./s1

SMILES string

CC(O)=O.N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc3ccc(O)cc3)NC1=O)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O

biological source

synthetic (organic)

sterility

non-sterile

assay

≥95% (HPLC)

form

powder

solubility

water: 20.0-20.8 mg/mL, clear, colorless to faintly yellow

UniProt accession no.

P01185, P30518, P37288, P47901

shipped in

ambient

storage temp.

−20°C

Quality Level

200

Gene Information

human ... AVP(551), AVPR1A(552), AVPR1B(553), AVPR2(554)

관련 카테고리

General description

Arginine vasopressin is a nonapeptide. It is produced by anterior hypothalamus nerve cells.

Application

[Arg8]-Vasopressin acetate salt has been:
  • used as a vasopressin receptor agonist to test vasopressin receptors
  • used to evoke peripheral V1a receptor-mediated vasoconstriction
  • as a supplement in Ham′s F12/Dulbecco′s modified Eagle′s medium for proximal tubule and glomerular explant cell culture

Biochem/physiol Actions

Endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. Arg8-vasopressin is also a neurotransmitter in the central nervous system. It is implicated in a variety of physiological processes including diuresis, vasoregulation, and memory. Regulates water balance by antidiuretic action; contracts arterioles (vasopressor action).
Endogenous antidiuretic hormone in most mammalian species; neurotransmitter in the central nervous system implicated in a variety of physiological processes including diuresis, vasoregulation, and memory.

Preparation Note

[Arg8]-Vasopressin acetate salt dissolves water at 20 mg/ml to yield a clear colorless to faint yellow solution.

Other Notes

Lyophilized from 0.5% acetic acid

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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시험 성적서(COA)

Lot/Batch Number
0000453305
0000453304
0000453304
0000453305
0000415136

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문서 라이브러리 방문

Voluntary locomotion linked with cerebral activation is mediated by vasopressin V1a receptors in free-moving mice
Masuki S, et al.
The Journal of Physiology, 591(14), 3651-3665 (2013)
Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin-neurophysin II precursor
Land H, et al.
Nature, 295(5847), 299-299 (1982)
Daniel J van Wamelen et al.
Sleep, 36(1), 117-125 (2013-01-05)
To study whether sleep and circadian rhythm disturbances in patients with Huntington's disease (HD) arise from dysfunction of the body's master clock, the hypothalamic suprachiasmatic nucleus. Postmortem cohort study. Eight patients with HD and eight control subjects matched for sex
Rare incorporation of bone marrow-derived cells into kidney after folic acid-induced injury
Szczypka MS, et al.
Stem Cells, 23(1), 44-54 (2005)
Medical Physiology, 424-424 (2009)
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