Z2626
Zaragozic acid A trisodium salt
from microbial, ≥95% (HPLC), lyophilized powder, squalene synthase inhibitor
동의어(들):
L-694,599, Squalestatin
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C35H43O14Na3
CAS 번호:
Molecular Weight:
756.68
UNSPSC Code:
12352106
NACRES:
NA.77
MDL number:
제품 이름
Zaragozic acid A trisodium salt, ≥95% (HPLC), microbial
biological source
microbial
assay
≥95% (HPLC)
form
lyophilized powder
solubility
DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
shipped in
wet ice
storage temp.
−20°C
Quality Level
Application
Zaragozic acid A trisodium salt has been used as:
- a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
- a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
- a cholesterol synthesis inhibitor in T cells
Biochem/physiol Actions
Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.
Legal Information
Manufactured and sold under a restricted license from Merck & Co., Inc., Kenilworth, NJ, U.S.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling
So T, et al.
Journal of immunology (Baltimore, Md. : 1950), 186(6), 3547-3555 (2011)
Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes
Griffin S, et al.
Biology of Reproduction, 99(4), 749-760 (2018)
Topical mevastatin promotes wound healing by inhibiting the transcription factor c-Myc via the glucocorticoid receptor and the long non-coding RNA Gas5
Sawaya AP, et al.
Test, 293(4), 1439-1449 (2018)
Kaitlyn M Dykstra et al.
Oncotarget, 6(39), 41535-41549 (2015-11-26)
Multiple myeloma (MM) is characterized by the production of monoclonal protein (MP). We have shown previously that disruption of the isoprenoid biosynthetic pathway (IBP) causes a block in MP secretion through a disruption of Rab GTPase activity, leading to an
Y Ichinose et al.
Gene, 80(2), 315-323 (1989-08-15)
We have isolated cDNA clones encoding the mouse cytokeratin No. 19 (Ck 19) from an intestinal cDNA library using synthetic oligodeoxyribonucleotides as probes. We obtained four independent clones, which correspond to about 1.4-kb of ck19 cDNA. Nucleotide sequence analysis revealed
문서
지질 신호전달 연구를 위한 생체 활성 저분자
Discover Bioactive Small Molecules for Lipid Signaling Research
관련 콘텐츠
Instructions
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.