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Merck

850371C

Avanti

22:0 PC

Avanti Research - A Croda Brand

Sinónimos:

1,2-didocosanoyl-sn-glycero-3-phosphocholine; PC(22:0/22:0)

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Fórmula empírica (notación de Hill):
C52H104NO8P
Número CAS:
Peso molecular:
902.36
MDL number:
UNSPSC Code:
51191904
NACRES:
NA.25
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Nombre del producto

22:0 PC, 1,2-dibehenoyl-sn-glycero-3-phosphocholine, chloroform

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (850371C-25mg), pkg of 1 × 20 mL (850371C-500mg)

manufacturer/tradename

Avanti Research - A Croda Brand 850371C

concentration

10 mg/mL (850371C-25mg), 25 mg/mL (850371C-500mg)

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[P](=O)([O-])(OCC[N+](C)(C)C)OCC(OC(=O)CCCCCCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCCCCCC

InChI

1S/C52H104NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-40-42-44-51(54)58-48-50(49-60-62(56,57)59-47-46-53(3,4)5)61-52(55)45-43-41-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h50H,6-49H2,1-5H3

InChI key

HRTBOPUWPUXROO-UHFFFAOYSA-N

General description

Phosphatidylcholines are phospholipids, that are abundantly present in the membrane. They have fatty acids in the sn-1 and sn-2 positions, that are covalently attached to a glycerol with the help of ester bonds.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

22:0 PC may be used:
  • to study its effects on non-amyloidogenic processing of amyloid precursor protein (APP)/α-secretase activity
  • to prepare a lipid monolayer to study whether ligand is specifically targeted to domains containing Cu(II)-iminodiacetate lipid (Cu-PSIDA)
  • as a lipid standard for the quantification of lipid species from lipid droplets by hydrophilic interaction liquid chromatography-high performance liquid chromatography (HILIC-HPLC)

Biochem/physiol Actions

The physical properties of membranes can be modulated with the help of fatty acyl configuration of phosphatidylcholines. They act as a vital source for eicosanoids.

Packaging

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (850371C-500mg)
5 mL Clear Glass Sealed Ampule (850371C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC


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pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Liver,Kidney, Respiratory system

Clase de almacenamiento

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash



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Elinor Thompson et al.
Healthcare technology letters, 6(5), 138-142 (2019-12-14)
Oxygen loaded microbubbles are being investigated as a means of reducing tumour hypoxia in order to improve response to cancer therapy. To optimise this approach, it is desirable to be able to measure changes in tissue oxygenation in real-time during
K Maloney et al.
Chemistry & biology, 3(3), 185-192 (1996-03-01)
Chemical information is sometimes transmitted across cell membranes by ligand-induced assembly of receptors. We have previously designed a series of lipids with metal-chelating headgroups that can serve as general receptors for proteins containing accessible histidines. Such lipids can also be
Pinunta Nittayacharn et al.
Frontiers in pharmacology, 11, 644-644 (2020-06-02)
Drug delivery to solid tumors using echogenic nanobubbles (NBs) and ultrasound (US) has recently gained significant interest. The approach combines attributes of nanomedicine and the enhanced permeation and retention (EPR) effect with the documented benefits of ultrasound to improve tumor