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Merck

860524P

Avanti

C24 Ceramide (d18:1/24:0)

Avanti Research - A Croda Brand

Sinónimos:

N-lignoceroyl-D-erythro-sphingosine

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Acerca de este artículo

Fórmula empírica (notación de Hill):
C42H83NO3
Número CAS:
Peso molecular:
650.11
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
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assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (860524P-10mg), pkg of 1 × 5 mg (860524P-5mg), pkg of 1 × 50 mg (860524P-50mg)

manufacturer/tradename

Avanti Research - A Croda Brand

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC[C@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC

InChI

1S/C42H83NO3/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-42(46)43-40(39-44)41(45)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2/h35,37,40-41,44-45H,3-34,36,38-39H2,1-2H3,(H,43,46)/b37-35+/t40-,41+/m0/s1

InChI key

ZJVVOYPTFQEGPH-AUTSUKAISA-N

General description

C24 Ceramide has long acyl chain length of 24 carbon units.

Application

C24 Ceramide (d18:1/24:0) has been used:
  • in the generation of small unilamellar vesicles
  • as an internal standard in liquid chromatography-mass spectrometry for ceramide quantification from rat samples
  • to test its effect on mitochondrial stress response in worms

Biochem/physiol Actions

C24 ceramide induces mitochondrial stress response. Its levels are depleted in coronary artery disease (CAD). However, elevated ceramide levels is observed in Alzheimer′s disease. C24 is synthesized during stress. It mediates spontaneous neutrophil death.

Packaging

5 mL Amber Glass Screw Cap Vial (860524P-10mg)
5 mL Amber Glass Screw Cap Vial (860524P-50mg)
5 mL Amber Glass Screw Cap Vial (860524P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC


Clase de almacenamiento

11 - Combustible Solids



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Ceramides and sphingomyelinases in senile plaques
Panchal M, et al.
Neurobiology of Disease, 65, 193-201 (2014)
Permeability and microstructure of model stratum corneum lipid membranes containing ceramides with long (C16) and very long (C24) acyl chains
Pullmannova P, et al.
Biophysical Chemistry, 224, 20-31 (2017)
Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides
Kauhanen D, et al.
Analytical and Bioanalytical Chemistry, 408(13), 3475-3483 (2016)