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365253

Gö 6976

InSolution, ≥95%, Inhibitor of protein kinase C

Sinónimos:

InSolution Gö 6976, Go 6976, Solution, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole

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Fórmula empírica (notación de Hill):
C24H18N4O
Número CAS:
136194-77-9
Peso molecular:
378.43
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00236434
Assay:
≥95% (HPLC)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze, protect from light
Servicio técnico
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Quality Level

100

assay

≥95% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

solubility

DMSO: 5 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

[n]1(c2c3[n](c4c(c3c5c(c2c6c1cccc6)CNC5=O)cccc4)C)CCC#N

InChI

1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)

InChI key

VWVYILCFSYNJHF-UHFFFAOYSA-N

General description

Inhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKCα-isozyme (IC50 = 2.3 nM) and PKCβI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC δ-, ε-, and ζ-isoenzymes even at micromolar levels. A potent antagonist of HIV-1 induction.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PKC
Product competes with ATP.
Reversible: yes
Target IC50: 7.9 nM, 2.3 nM, and 6.2 nM, for rat brain PKC, Ca2+-dependent PKC α-isozyme, and PKCβI, respectively

Packaging

Packaged under inert gas

Physical form

A 500 µg/ml solution of Gö 6976 (Cat. No. 365250) in anhydrous DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Gschwendt, M., et al. 1996. FEBS Lett.392, 77.
Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun.200, 1536.
Martiny-Baron, G., et al. 1993. J. Biol. Chem.268, 9194.
Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA90, 674.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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Clase de almacenamiento

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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