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Merck

475880

ML-7 Hydrochloride

>98% (TLC), protein kinase A and C inhibitor, solid

Sinónimos:

ML-7, Hydrochloride, 1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl

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About This Item

Fórmula empírica (notación de Hill):
C15H17IN2O2S · xHCl
Número CAS:
110448-33-4
Peso molecular:
416.28 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00065524

Nombre del producto

ML-7, Hydrochloride, A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM).

SMILES string

Ic1c2c(c(ccc2)[S](=O)(=O)N3CCNCCC3)ccc1

InChI

1S/C15H17IN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2

InChI key

GEHJIACZUFWBTK-UHFFFAOYSA-N

assay

>98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

50% ethanol: 4.5 mg/mL
DMSO: 4.5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Categorías relacionadas

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Myosin light chain kinase (Mlck)
Product competes with ATP.
Reversible: yes
Target Ki: 300 nM against myosin light chain kinase

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM)and protein kinase C (Ki = 42 µM) at much higher concentrations.

Other Notes

Krarup, T., et al. 1998. Am. J. Physiol. 275, C239.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Further dilute with aqueous buffer just prior to use.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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