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506153

p38 MAP Kinase Inhibitor IV

Name: p38 MAP Kinase Inhibitor IV
Brand: MM

The p38 MAP Kinase Inhibitor IV, also referenced under CAS 1638-41-1, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sinónimos:

p38 MAP Kinase Inhibitor IV, 2,2ʹ-Sulfonyl-bis-(3,4,6-trichlorophenol), MT4

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Fórmula empírica (notación de Hill):

C₁₂H₄Cl₆O₄S

Número CAS:

1638-41-1

Peso molecular:

456.94

MDL number:

MFCD00397032

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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Propiedades

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

light yellow

solubility

DMSO: 4.5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(c2c(c(cc(c2O)Cl)Cl)Cl)c1c(c(cc(c1O)Cl)Cl)Cl

InChI

1S/C12H4Cl6O4S/c13-3-1-5(15)9(19)11(7(3)17)23(21,22)12-8(18)4(14)2-6(16)10(12)20/h1-2,19-20H

InChI key

AKUKHICVNCCQHN-UHFFFAOYSA-N

Descripción

General description

A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC₅₀ = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 µM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 µM respective inhibitor).

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Liu, Y.C., et al. 2007. Biochem. Biophys. Res. Commun.352, 656.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c