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Merck

F0700000

Furosemide

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid

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About This Item

Fórmula empírica (notación de Hill):
C12H11ClN2O5S
Número CAS:
54-31-9
Peso molecular:
330.74
NACRES:
NA.24
PubChem Substance ID:
329799665
UNSPSC Code:
41116107
MDL number:
MFCD00010549

Nombre del producto

Furosemide, European Pharmacopoeia (EP) Reference Standard

InChI key

ZZUFCTLCJUWOSV-UHFFFAOYSA-N

SMILES string

NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl

InChI

1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)

grade

pharmaceutical primary standard

API family

furosemide

manufacturer/tradename

EDQM

mp

220 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... SLC12A1(6557)

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Categorías relacionadas

Application

Furosemide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Inhibits ion co-transport in the kidney.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Case scenario: Hemodynamic management of postoperative acute kidney injury.
Matthieu Legrand et al.
Anesthesiology, 118(6), 1446-1454 (2013-04-06)
Maarten C van Loon et al.
Hearing research, 298, 17-26 (2013-01-31)
It is well known that spiral ganglion cells (SGCs) degenerate in hair-cell-depleted cochleas and that treatment with exogenous neurotrophins can prevent this degeneration. Several studies reported that, in addition, SGC size decreases after deafening and increases after neurotrophic treatment. The
Naoki Sato et al.
Circulation journal : official journal of the Japanese Circulation Society, 77(4), 944-951 (2013-03-19)
Hospitalized heart failure (HHF) is a critical issue in Japan. To improve its management and outcomes, the clinical features, in-hospital management, and outcomes should be analyzed to improve the guidelines for HHF. The acute decompensated heart failure syndromes (ATTEND) registry
Christianne L Roumie et al.
Stroke, 46(2), 465-470 (2015-01-01)
We examined blood pressure 1 year after stroke discharge and its association with treatment intensification. We examined the systolic blood pressure (SBP) stratified by discharge SBP (≤140, 141-160, or >160 mm Hg) among a national cohort of Veterans discharged after
F H Wilson et al.
Science (New York, N.Y.), 293(5532), 1107-1112 (2001-08-11)
Hypertension is a major public health problem of largely unknown cause. Here, we identify two genes causing pseudohypoaldosteronism type II, a Mendelian trait featuring hypertension, increased renal salt reabsorption, and impaired K+ and H+ excretion. Both genes encode members of
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