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Merck

L0400000

3,4-Dihidroxi-L-fenilalanina

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

3-(3,4-Dihidroxifenil)-L-alanina, L-3-Hidroxitirosina, L-DOPA, Levodopa

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Acerca de este artículo

Fórmula lineal:
(HO)2C6H3CH2CH(NH2)CO2H
Número CAS:
59-92-7
Peso molecular:
197.19
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329817362
MDL number:
MFCD00002598
Beilstein/REAXYS Number:
2215169

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Nombre del producto

3,4-Dihidroxi-L-fenilalanina, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1

SMILES string

N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O

InChI key

WTDRDQBEARUVNC-LURJTMIESA-N

grade

pharmaceutical primary standard

API family

levodopa

manufacturer/tradename

EDQM

mp

276-278 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... DRD3(1814)

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Application

Levodopa EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number

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Nicolas Morin et al.
Experimental neurology, 256, 105-116 (2013-01-31)
The treatment of motor symptoms of Parkinson disease (PD) with the dopamine (DA) precursor, l-3,4-dihydroxyphenylalanine (l-DOPA) introduced 50years ago still remains a very effective medication. However, involuntary movements termed l-DOPA-induced dyskinesias (LID) appear in the vast majority of PD patients
Lukas L Imbach et al.
Parkinsonism & related disorders, 20(11), 1283-1286 (2014-09-28)
Diagnosis and treatment of tremor are largely based on clinical assessment. Whereas in some patients tremor may respond to dopaminergic treatment, in general l-Dopa response to tremor varies considerably. The aim of this study was to predict l-Dopa response by
Elahe Molaakbari et al.
The Analyst, 139(17), 4356-4364 (2014-07-12)
A novel carbon paste electrode modified with ZnO nanorods and 5-(4'-amino-3'-hydroxy-biphenyl-4-yl)-acrylic acid (3,4'-AAZCPE) was fabricated. The electrochemical study of the modified electrode, as well as its efficiency for the electrocatalytic oxidation of levodopa, is described. The electrode was employed to
M Purschke et al.
The British journal of dermatology, 172(4), 1021-1028 (2014-10-14)
Epidermal suction blister grafts are an effective treatment for chronic wounds or vitiligo, but this treatment is time consuming and limited to small areas. To compare two novel strategies to create fractional epidermal grafts. Epidermal blisters were raised from fresh
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