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Merck

PHR1102

L-cisteína hydrochloride monohydrate

Pharmaceutical Secondary Standard; Certified Reference Material

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About This Item

Fórmula lineal:
HSCH2CH(NH2)COOH · HCl · H2O
Número CAS:
7048-04-6
Peso molecular:
175.63
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823124
EC Number:
200-157-7
Beilstein/REAXYS Number:
5158059
MDL number:
MFCD00065606

Nombre del producto

L-cisteína hydrochloride monohydrate, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

QIJRTFXNRTXDIP-JIZZDEOASA-N

InChI

1S/C3H7NO2S.ClH.H2O/c4-2(1-7)3(5)6;;/h2,7H,1,4H2,(H,5,6);1H;1H2/t2-;;/m0../s1

SMILES string

O.Cl.N[C@@H](CS)C(O)=O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. C3290000
traceable to USP 1161509

API family

cysteine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Categorías relacionadas

Biochem/physiol Actions

Antagonista del receptor glutamatérgico NMDA.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

L-Cysteine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography, and kinetic micro determination coupled to spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

L-Cysteine hydrochloride monohydrate (LCHCMH) is a water-soluble salt of the non-essential amino acid, L-cysteine.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7165 in the slot below. This is an example certificate only and may not be the lot that you receive.

Clase de almacenamiento

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Indicator reaction for sensitive kinetic micro-determination of cysteine and cystine in a mixture without prior separation
Giannousios A and Papadopoulos C
Analyst, 121(4), 413-417 (1996)
Simultaneous identification and determination of total content of aminoacids in food supplements-tablets by gas chromatography
Obreshkova DP, et al.
Asian Journal of Pharmaceutical and Clinical Research, 5, 57-68 (2012)
Qinjian Zhao et al.
Human vaccines & immunotherapeutics, 10(3), 734-739 (2013-12-05)
Cryo-transmission electron microscopy (cryoTEM) is a powerful characterization method for assessing the structural properties of biopharmaceutical nanoparticles, including Virus Like Particle-based vaccines. We demonstrate the method using the Human Papilloma Virus (HPV) VLPs in GARDASIL®. CryoTEM, coupled to automated data
Edward T Chouchani et al.
Nature medicine, 19(6), 753-759 (2013-05-28)
Oxidative damage from elevated production of reactive oxygen species (ROS) contributes to ischemia-reperfusion injury in myocardial infarction and stroke. The mechanism by which the increase in ROS occurs is not known, and it is unclear how this increase can be
Indira Wu et al.
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Numerous protein engineering studies have focused on increasing the thermostability of fungal cellulases to improve production of fuels and chemicals from lignocellulosic feedstocks. However, the engineered enzymes still undergo thermal inactivation at temperatures well below the inactivation temperatures of hyperthermophilic
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