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About This Item
Fórmula lineal:
H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
Número CAS:
Peso molecular:
307.32
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1729812
Nombre del producto
L-Glutatión reducido, European Pharmacopoeia (EP) Reference Standard
InChI
1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
SMILES string
N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O
InChI key
RWSXRVCMGQZWBV-WDSKDSINSA-N
grade
pharmaceutical primary standard
API family
glutathione
manufacturer/tradename
EDQM
mp
192-195 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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Application
Puede utilizarse a 5-10 mM para eluir la glutatión S-transferasa (GST) a partir de glutatión agarosa.
Biochem/physiol Actions
Antioxidante endógeno que desempeña un papel importante en la reducción de las especies de oxígeno reactivo formadas durante el metabolismo celular y el estallido respiratorio. La glutatión-S-transferasa cataliza la formación de tioéteres de glutatión con xenobióticos, leucotrienos y otras moléculas que tienen un centro electrofílico. El glutatión también forma enlaces de disulfuro con restos de cisteína de las proteínas. A través de estos mecanismos, puede tener el efecto paradójico de reducir la eficacia de los antineoplásicos.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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