A6816
(±)-AMPA
solid
Sinónimos:
(±)-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrate
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C7H10N2O4
Peso molecular:
186.17
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Form:
solid
Quality level:
Servicio técnico
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solid
Quality Level
color
white
solubility
H2O: 1 mg/mL (warm), 0.1 M HCl: 3.5 mg/mL, 0.1 M NaOH: 4.3 mg/mL, DMSO: 4.3 mg/mL, 1 M HCl: 50 mg/mL
SMILES string
O.Cc1onc(O)c1CC(N)C(O)=O
InChI
1S/C7H10N2O4.H2O/c1-3-4(6(10)9-13-3)2-5(8)7(11)12;/h5H,2,8H2,1H3,(H,9,10)(H,11,12);1H2
InChI key
HFISYNCCKQHIAM-UHFFFAOYSA-N
Gene Information
Application
(±)-AMPA has been used:
- in vivo
- whole-cell patch-clamp recording in Müller glial cells
- to test its excitotoxic effects in hippocampal slice cultures
- in retinal horizontal cells (HCs) culture to test its effect on Ca2+ signals
Biochem/physiol Actions
Potent excitatory amino acid that interacts selectively with central AMPA/kainate receptors.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Carlos Gonzalez-Islas et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(39), 13597-13607 (2012-09-28)
Endocannabinoid signaling has been shown to mediate synaptic plasticity by retrogradely inhibiting presynaptic transmitter release in several systems. We found that endocannabinoids act tonically to regulate AMPA miniature postsynaptic current (mPSC) frequency in embryonic motor circuits of the chick spinal
Stuti J Jaiswal et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(6), 2616-2625 (2013-02-09)
Developmental nicotine exposure (DNE) impacts central respiratory control in neonates born to smoking mothers. We previously showed that DNE enhances the respiratory motor response to bath application of AMPA to the brainstem, although it was unclear which brainstem respiratory neurons
Timm Schubert et al.
Neuron, 78(1), 124-137 (2013-04-16)
Presynaptic inhibition onto axons regulates neuronal output, but how such inhibitory synapses develop and are maintained in vivo remains unclear. Axon terminals of glutamatergic retinal rod bipolar cells (RBCs) receive GABAA and GABAC receptor-mediated synaptic inhibition. We found that perturbing GABAergic