D1916
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside
≥98% (HPLC), powder, RNA synthesis inhibitor
Sinónimos:
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole, 5,6-Dichlorobenzimidazole riboside, DRB
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Fórmula empírica (notación de Hill):
C12H12Cl2N2O4
Número CAS:
Peso molecular:
319.14
UNSPSC Code:
12352200
eCl@ss:
32151902
PubChem Substance ID:
NACRES:
NA.77
Beilstein/REAXYS Number:
39123
MDL number:
Form:
powder
Quality level:
Servicio técnico
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Permítanos ayudarleNombre del producto
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside,
Quality Level
form
powder
storage temp.
−20°C
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3cc(Cl)c(Cl)cc23
InChI
1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1
InChI key
XHSQDZXAVJRBMX-DDHJBXDOSA-N
Gene Information
human ... CSNK2A1(1457), CSNK2B(1460)
Application
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside has been used:
- as an inhibitor of RNA polymerase II in mouse melanoma cells
- for the inhibition of cyclin D1 mRNA synthesis in human prostate epithelial cell lines
- in the inhibition of interleukin-2 gene transcription in Jurkat cells
Biochem/physiol Actions
Inhibitor of RNA synthesis; causes premature termination of transcription. CK2 (casein kinase-2) inhibitor.
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB), a nucleoside analog that halts mRNA synthesis by phosphorylation of the C-terminal domain of RNA polymerase II, making it inactive. It also interferes with the DNA topoisomerase II, may modulate response to cytokines and blocks the human immunodeficiency virus (HIV) via RNA modification. It also inhibits cyclin-dependent kinases (CDKs) 7 and 9 and favors apoptosis in leukemic cells. It may serve as a therapeutic agent in treating cancer.
Features and Benefits
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Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Instructions
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