F3680

10058-F4

Name: 10058-F4
Brand: SIGMA

≥98% (HPLC), c-Myc inhibitor, solid

Sinónimos:

5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

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About This Item

Fórmula empírica (notación de Hill):

C₁₂H₁₁NOS₂

Número CAS:

403811-55-2

Peso molecular:

249.35

UNSPSC Code:

12352200

PubChem Substance ID:

329799701

NACRES:

NA.77

MDL number:

MFCD00758517

Nombre del producto

10058-F4, ≥98% (HPLC), solid

SMILES string

CCc1ccc(cc1)\C=C2\SC(=S)NC2=O

InChI key

SVXDHPADAXBMFB-JXMROGBWSA-N

InChI

1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

DMSO: >10 mg/mL
H₂O: <2 mg/mL

storage temp.

2-8°C

Quality Level

100

Categorías relacionadas

Inhibidores bioactivos de moléculas pequeñas

Pequeñas moléculas bioactivas

Application

10058-F4 has been used:

as c-Myc inhibitor to treat stromal cells
as c-Myc inhibitor to determine the effect of c-Myc inhibition on cardiac progenitor cells (CPC) growth
as c-Myc inhibitor to culture T cells
to treat C4-2 cells to examine the activity of MST1 promoter luciferase reporter construct

Biochem/physiol Actions

10058-F4 is a c-Myc inhibitor that induces cell-cycle arrest and apoptosis. 10058-F4 is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 inhibits tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 μM using c-Myc transfected Rat1a fibroblasts).

10058-F4 is a c-Myc inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

GHS07

signalword

Warning

hcodes

H317,H319

pcodes

P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análisis (COA)

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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Overexpression of MYC and EZH2 cooperates to epigenetically silence MST1 expression

Kuser-Abali G, et al.

Epigenetics, 9(4), 634-643 (2014)

Neuroblastoma patient-derived xenograft cells cultured in stem-cell promoting medium retain tumorigenic and metastatic capacities but differentiate in serum.

Camilla U Persson et al.

Scientific reports, 7(1), 10274-10274 (2017-09-02)

Cultured cancer cells serve as important models for preclinical testing of anti-cancer compounds. However, the optimal conditions for retaining original tumor features during in vitro culturing of cancer cells have not been investigated in detail. Here we show that serum-free

cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response

Madapura HS, et al.

Cell Cycle, 15(9), 1267-1275 (2016)

Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential

Bellio MA, et al.

Scientific reports, 7(1), 9702-9702 (2017)

Concerted Action of PGC-1-related Coactivator (PRC) and c-MYC in the Stress Response to Mitochondrial Dysfunction.

Natalie Gleyzer et al.

The Journal of biological chemistry, 291(49), 25529-25541 (2016-10-30)

PGC-1-related coactivator (PRC) has a dual function in growth-regulated mitochondrial biogenesis and as a sensor of metabolic stress. PRC induction by mitochondrial inhibitors, intracellular ROS, or topoisomerase I inhibition orchestrates an inflammatory program associated with the adaptation to cellular stress.

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