I8021
L-N6-(1-Iminoethyl)lysine dihydrochloride
Sinónimos:
L-Lysine ω-acetamidine dihydrochloride, L-NIL dihydrochloride
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C8H17N3O2 · 2 HCl
Número CAS:
Peso molecular:
260.16
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
Servicio técnico
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Permítanos ayudarlebiological source
synthetic (organic)
assay
≥97% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
Cl.Cl.CC(=N)NCCCC[C@H](N)C(O)=O
InChI
1S/C8H17N3O2.2ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13;;/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);2*1H/t7-;;/m0../s1
InChI key
OQIBCXRAFAHXMM-KLXURFKVSA-N
Gene Information
human ... NOS2(4843)
Application
L-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor:
- to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine
- to study its effects on leptin-induced inflammation in hepatocytes
- to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)
Biochem/physiol Actions
Selective inhibitor of inducible nitric oxide synthase (iNOS).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Sara Becerril et al.
Genes, 10(3) (2019-03-02)
iNOS deficiency in ob/ob mice improved liver inflammation and ECM remodeling-related genes, decreasing fibrosis, and metabolic dysfunction. The activation of iNOS by leptin is necessary for the synthesis and secretion of TNC in hepatocytes, suggesting an important role of this
W M Moore et al.
Journal of medicinal chemistry, 37(23), 3886-3888 (1994-11-11)
L-N6-(1-Iminoethyl)lysine (L-NIL) has been synthesized and is shown to be both a potent and selective inhibitor of mouse inducible nitric oxide synthase (miNOS). L-NIL has an IC50 of 3.3 microM for miNOS compared to an IC50 of 92 microM for
Nikolai V Gorbunov et al.
Journal of cellular and molecular medicine, 19(5), 1133-1150 (2015-02-28)
The bone marrow stroma constitutes the marrow-blood barrier, which sustains immunochemical homoeostasis and protection of the haematopoietic tissue in sequelae of systemic bacterial infections. Under these conditions, the bone marrow stromal cells affected by circulating bacterial pathogens shall elicit the