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I9785

Imidazolo-oxindole PKR inhibitor C16

Name: Imidazolo-oxindole PKR inhibitor C16
Brand: SIGMA

≥98% (HPLC), RNA-dependent protein kinases (PKR, Eif2ak2) inhibitor

Sinónimos:

6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one

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Acerca de este artículo

Fórmula empírica (notación de Hill):

C₁₃H₈N₄OS

Número CAS:

608512-97-6

Peso molecular:

268.29

UNSPSC Code:

12352200

PubChem Substance ID:

329815469

NACRES:

NA.77

MDL number:

MFCD06735404

Assay:

≥98% (HPLC)

Quality level:

100

Servicio técnico

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Propiedades

Nombre del producto

Imidazolo-oxindole PKR inhibitor C16, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

color

yellow to orange-brown

solubility

DMSO: 12 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

O=C1NC2=CC=C3C(SC=N3)=C2/C1=C/C4=CNC=N4

InChI

1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-

InChI key

VFBGXTUGODTSPK-BAQGIRSFSA-N

Descripción

Application

Imidazolo-oxindole PKR inhibitor C16 has been used:

to rescue fear memory deficits and restore long-term potentiation (LTP) impairment in mice
to inhibit the strong induction of interferon stimulated genes (ISGs) after plasmid transfection in HeLa-S3 cells
to augment eukaryotic translation initiation factor 2 (eIF2) activity

Biochem/physiol Actions

C16 exhibits a neuroprotective role in adult brain injuries.

Imidazolo-oxindole PKR inhibitor C16 is a selectiv inhibitor of RNA-dependent protein kinases (PKR, Eif2ak2).

Imidazolo-oxindole PKR inhibitor C16 is a selective inhibitor of RNA-dependent protein kinases (PKR, Eif2ak2). C16 is a first reported, potent and selective PKR inhibitor. Its inhibition effect on PKR is ATP-binding site directed. C16 specifically inhibits the apoptotic PKR/eIF2a signaling pathway without stimulating the proliferative mTOR/p70S6K signaling mechanism.

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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The specific protein kinase R (PKR) inhibitor C16 protects neonatal hypoxia-ischemia brain damages by inhibiting neuroinflammation in a neonatal rat model

Xiao J, et al.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 22, 5074-5074 (2016)

PKR-a Kinase to Remember

Gal-Ben-Ari S, et al.

Frontiers in Molecular Neuroscience, 11, 480-480 (2018)

A screening strategy for the discovery of drugs that reduce C/EBPβ-LIP translation with potential calorie restriction mimetic properties.

Mohamad A Zaini et al.

Scientific reports, 7, 42603-42603 (2017-02-16)

An important part of the beneficial effects of calorie restriction (CR) on healthspan and lifespan is mediated through regulation of protein synthesis that is under control of the mechanistic target of rapamycin complex 1 (mTORC1). As one of its activities

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