T6700
TRAM-34
≥98% (HPLC), Ca2+-activated K+ channel inhibitor, solid
Sinónimos:
1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C22H17ClN2
Número CAS:
Peso molecular:
344.84
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Permítanos ayudarleNombre del producto
TRAM-34, ≥98% (HPLC), solid
SMILES string
Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4
InChI key
KBFUQFVFYYBHBT-UHFFFAOYSA-N
InChI
1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
assay
≥98% (HPLC)
form
solid
color
off-white
solubility
DMSO: 2 mg/mL, H2O: insoluble
storage temp.
2-8°C
Quality Level
Categorías relacionadas
Application
TRAM-34 has been used to study its effect on the prevention of vascular restenosis after balloon angioplasty.
Biochem/physiol Actions
TRAM-34 exhibits 100-fold selectivity (Kd = 20 nM) for IKCa1 channels over other K+ channels (Charybdotoxin, Kd = 5 nM, Clotrimazole, Kd = 70 nM; Nitrendipine Kd = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.
TRAM-34 is a potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
TRAM-34 is soluble in DMSO at 2 mg/ml. However, it is insoluble in water.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 4
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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H Wulff et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(14), 8151-8156 (2000-07-08)
The antimycotic clotrimazole, a potent inhibitor of the intermediate-conductance calcium-activated K(+) channel, IKCa1, is in clinical trials for the treatment of sickle cell disease and diarrhea and is effective in ameliorating the symptoms of rheumatoid arthritis. However, inhibition of cytochrome
Friederike A Steudel et al.
Molecular oncology, 11(9), 1172-1188 (2017-05-31)
Oncogenic signalling via Ca
Zhihua Yu et al.
Frontiers in cellular neuroscience, 11, 319-319 (2017-10-28)
Ischemic stroke is a devastating neurological disease that can initiate a phenotype switch in astrocytes. Reactive astrogliosis is a significant pathological feature of ischemic stroke and is accompanied by changes in gene expression, hypertrophied processes and proliferation. The intermediate-conductance Ca
K George Chandy et al.
Trends in pharmacological sciences, 25(5), 280-289 (2004-05-04)
The voltage-gated Kv1.3 channel and the Ca(2+)-activated IKCa1 K(+) channel are expressed in T cells in a distinct pattern that depends on the state of lymphocyte activation and differentiation. The channel phenotype changes during the progression from the resting to
Crocin Improves the Endothelial Function Regulated by Kca3.1 Through ERK and Akt Signaling Pathways.
Huike Yang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 46(2), 765-780 (2018-04-06)
Based on the protective effect of crocin against cardiovascular diseases, we hypothesize that crocin could improve endothelial function through activating the eNOS(endothelial nitric oxide synthase) /NO pathway and/or the intermediate-conductance Ca2+-activated K+ channels (KCa3.1). In this study, rat aortic rings
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