V116

Z-VAD-FMK

Name: Z-VAD-FMK
Brand: SIGMA

≥98% (TLC), solid, Caspase inhibitor

Sinónimos:

N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):

C₂₂H₃₀FN₃O₇

Número CAS:

187389-52-2

Peso molecular:

467.49

UNSPSC Code:

12352209

NACRES:

NA.77

MDL number:

MFCD01074990

Nombre del producto

Z-VAD-FMK, solid

SMILES string

FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C)CC(=O)OC

InChI

1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1

InChI key

MIFGOLAMNLSLGH-QOKNQOGYSA-N

biological source

synthetic

assay

≥98% (TLC)

form

solid

color

white

solubility

DMSO: 20 mg/mL
H₂O: insoluble

storage temp.

−20°C

Application

Z-VAD-FMK has been used:

to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells
to induce autophagy in Jurkat and K562 cells
to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines
as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53

Biochem/physiol Actions

Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.

Disclaimer

Hygroscopic

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Z-VAD-FMK inhibits yeast and mammalian peptide N-glycanase (PNGase). It induces apoptosis. Z-VAD-FMK might be associated with endoplasmic reticulum (ER) stress.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Apoptosis inhibition can be threatening in Abeta-induced neuroinflammation, through promoting cell proliferation

Abdi A, et al.

Neurochemical Research, 36(1), 39-48 (2011)

z-VAD-fmk inhibits peptide: N-glycanase and may result in ER stress

Misaghi S, et al.

Cell Death and Differentiation, 13(1), 163-163 (2006)

Deletion of Ripk3 prevents Motor Neuron death in vitro but not in vivo

Dermentzaki G, et al.

eNeuro, ENEURO-EN0308 (2019)

Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation.

Peng Chen et al.

Theranostics, 10(11), 5107-5119 (2020-04-21)

Background and Purpose: RAS mutations limit the effectiveness of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies in combination with chemotherapy for metastatic colorectal cancer (mCRC) patients. Therefore, new cell death forms have focused on identifying indirect targets to inhibit Ras-induced

Increasing colorectal cancer cell sensitivity to oxaliplatin through hyperthermia and chloroquine treatment

Zheng C, et al.

International Journal of Clinical and Experimental Pathology, 9(2), 496-508 (2016)

Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico